ArticleOpen access Macedonian journal of medical sciences2019
Pharmacokinetics of Nanosomal Form of Levodopa in Intranasal Administration.
Article in Open access Macedonian journal of medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 7 citations in OpenAlex.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParkinson's disease is one of the most common neurological diseases. Pathogenesis of the disease is associated with destruction and death of neurons that produce the neurotransmitter dopamine. The precursor to dopamine, which crosses the protective blood-brain barrier, is the amino acid 3, 4-dihydroxy-L-phenylalanine - levodopa, L-DOPA. The investigational drug is a pharmaceutical composition, containing L-DOPA as an active substance, which is distributed in a polymer matrix based on a biodegradable copolymer of lactic/glycolic acids.
aimThis work aimed to study the main pharmacokinetic parameters for the drug "L-DOPA - PC, nasal drops" and comparator drugs "L-DOPA in oil", "L-DOPA - PC in purified water", reference product - tablets "Madopar 125".
methodsTo increase the bioavailability of the active substance L-DOPA, a new route of administration was used for the first time - nasal administration. Pharmacokinetics of the innovative drug with the intranasal route of administration was investigated in rabbits. The L-DOPA concentration in blood plasma was determined by high-performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS).
resultsBioavailability of the drug - nasal drops were 244.4% compared with the drug "Madopar 125".
conclusionAssay procedure for the determination of L-DOPA in animal blood plasma using liquid chromatography with tandem mass-selective detection (HPLC-MS/MS) was developed and validated.
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