Evidence map›Paper›PMID 32010311›Full record

ArticleExperimental and therapeutic medicine2020

The inhibitor of autophagy SBI-0206965 aggravates atherosclerosis through decreasing myeloid-derived suppressor cells.

Bo Wang, Guanjun Dong, Qingqiing Zhang, Fenglian Yan, Zhihua Li, Chunxia Li, Hui Zhang, Qun Ma, Jun Dai, Chuanping Si and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Experimental and therapeutic medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. The crosstalk between autophagy and myeloid-derived suppressor cell responses in cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Bo WangInstitute of Forensic Medicine and Laboratory Medicine, Jining Medical University, Jining, Shandong 272067, P.R. China.
Guanjun DongInstitute of Immunology and Molecular Medicine, Jining Medical University, Jining, Shandong 272067, P.R. China.
Qingqiing ZhangInstitute of Immunology and Molecular Medicine, Jining Medical University, Jining, Shandong 272067, P.R. China.
Fenglian YanInstitute of Immunology and Molecular Medicine, Jining Medical University, Jining, Shandong 272067, P.R. China.
Zhihua LiInstitute of Immunology and Molecular Medicine, Jining Medical University, Jining, Shandong 272067, P.R. China.
Chunxia LiInstitute of Immunology and Molecular Medicine, Jining Medical University, Jining, Shandong 272067, P.R. China.
Hui ZhangInstitute of Immunology and Molecular Medicine, Jining Medical University, Jining, Shandong 272067, P.R. China.
Qun MaInstitute of Immunology and Molecular Medicine, Jining Medical University, Jining, Shandong 272067, P.R. China.
Jun DaiInstitute of Immunology and Molecular Medicine, Jining Medical University, Jining, Shandong 272067, P.R. China.
Chuanping SiInstitute of Immunology and Molecular Medicine, Jining Medical University, Jining, Shandong 272067, P.R. China.
Huabao XiongDepartment of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Jining Medical University · CNIcahn School of Medicine at Mount Sinai · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerosis (AS) is currently the leading cause of mortality worldwide, with the development of new strategies to prevent the formation and rupture of atherosclerotic plaques being a paramount area of research. Amounting evidence suggests autophagy has an important role in the pathogenesis of AS and may be a potential therapeutic target. In this study, the effect of SBI-0206965(6965), a novel inhibitor of autophagy, was tested on the development of AS in apolipoprotein E deficient (ApoE

Indexed as

atherosclerosisautophagymyeloid-derived suppressor cellsplaque stabilitySBI-0206965

Identifiers

PMID32010311
PMCPMC6966176
OpenAlexW2994703054

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.