ArticleExperimental and therapeutic medicine2020
Pilose antler peptide promotes osteoblast proliferation, differentiation and mineralization via the insulin signaling pathway.
Article in Experimental and therapeutic medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Integrated bioinformatic and experimental analyses identify Lumican as a key regulator of LIPUS-induced osteogenesis through Integrin β1/FAK/ERK signaling.Molecular biology reports · 2026Article
- Combination of Pilose Antler Extract and Hydroxytyrosol Enhances Bone Mineral Density in Both Animals and Postmenopausal Women.Food science & nutrition · 2025Article
- Identification of Marker Peptides in Gelatins from Sika Deer (Molecules (Basel, Switzerland) · 2025Article
- Well-known polypeptides of deer antler velvet with key actives: modern pharmacological advances.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Application of polydopamine-modified triphasic PLA/PCL-PLGA/Mg(OH)Frontiers in bioengineering and biotechnology · 2024Article
- Sika deer velvet antler protein extract modulater bone metabolism and the structure of gut microbiota in ovariectomized mice.Food science & nutrition · 2023Article
- Effect of pilose antler polypeptide on the mechanism of bone homeostasis in osteoporosis.Frontiers in medicine · 2023Review
- Health Effects of Peptides Extracted from Deer Antler.Nutrients · 2022Review
- MAPK/ERK Pathway as a Central Regulator in Vertebrate Organ Regeneration.International journal of molecular sciences · 2022Review
- The Protective Effect of Pilose Antler Peptide on CUMS-Induced Depression Through AMPK/Sirt1/NF-κB/NLRP3-Mediated Pyroptosis.Frontiers in pharmacology · 2022Article
- Mechanism of Pilose Antler in Treatment of Osteoporosis Based on Network Pharmacology.Journal of healthcare engineering · 2022Article
- Use of Network Pharmacology and Molecular Docking Technology to Analyze the Mechanism of Action of Velvet Antler in the Treatment of Postmenopausal Osteoporosis.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- The Inhibitory Effect of Curcumin Derivative J147 on Melanogenesis and Melanosome Transport by Facilitating ERK-Mediated MITF Degradation.Frontiers in pharmacology · 2021Article
- Protoporphyrin IX Stimulates Melanogenesis, Melanocyte Dendricity, and Melanosome Transport Through the cGMP/PKG Pathway.Frontiers in pharmacology · 2020Article
- Low-molecular-weight peptides from deer antler velvet: Antioxidant potential, biosafety, and synergistic interaction with nanomelanin.Journal of advanced pharmaceutical technology & researchArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoporosis is a severe bone disease characterized by a decrease in the density and structure of bones, with high risks of fractures. Pilose antler peptide (PAP), extracted and purified from deer antlers, can promote regeneration and fracture healing, and strengthen sinews and bone. To determine whether PAP can promote osteoblast development and to elucidate the molecular mechanisms underlying its functions, the present study investigated the effects of PAP on osteoblast proliferation, differentiation and mineralization, and the role of the insulin signaling pathway using MTT assay, alkaline phosphatase activity assay, western blot analysis and reverse transcription-quantitative PCR. The present results suggested that PAP promoted osteoblast proliferation, differentiation and mineralization
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.