Evidence map›Paper›PMID 32010048›Full record

ArticleFrontiers in neurology2019

Expression of Cytokines and Chemokines as Predictors of Stroke Outcomes in Acute Ischemic Stroke.

Sarah R Martha, Qiang Cheng, Justin F Fraser, Liyu Gong, Lisa A Collier, Stephanie M Davis, Doug Lukins, Abdulnasser Alhajeri, Stephen Grupke, Keith R Pennypacker

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07754942 (Local-to-Systemic Inflammatory Biomarker Gradients and 90-Day Functional Outcomes in Patients With Acute Ischemic Stroke Due to Anterior Circulation Large Vessel Occlusion Undergoing Mechanical Thrombectomy), which is not on this map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07754942 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Local-to-Systemic Inflammatory Biomarker Gradients and 90-Day Functional Outcomes in Patients With Acute Ischemic Stroke Due to Anterior Circulation Large Vessel Occlusion Undergoing Mechanical Thrombectomy: A Prospective Observational Cohort Study

TypeobservationalSponsorZhongshan Hospital Xiamen UniversityRan2026 to 2029Enrolled50ConditionsAcute Ischemic Stroke, Large Vessel OcclusionArmsProspective Mechanical Thrombectomy Cohort
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Isolation and identification of leukocyte populations in intracranial blood collected during mechanical thrombectomy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Trial
  4. Review
  5. Article
  6. Review
  7. Review
  8. Applications of artificial intelligence in drug discovery for neurological diseases.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Observational
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Sarah R MarthaSchool of Nursing, University of Washington, Seattle, WA, United States.
Qiang ChengInstitute for Biomedical Informatics, University of Kentucky, Lexington, KY, United States.
Justin F FraserDepartment of Neurology, University of Kentucky, Lexington, KY, United States.
Liyu GongInstitute for Biomedical Informatics, University of Kentucky, Lexington, KY, United States.
Lisa A CollierDepartment of Neurology, University of Kentucky, Lexington, KY, United States.
Stephanie M DavisDepartment of Neurology, University of Kentucky, Lexington, KY, United States.
Doug LukinsCollege of Medicine, University of Kentucky, Lexington, KY, United States.
Abdulnasser AlhajeriDepartment of Neurology, University of Kentucky, Lexington, KY, United States.
Stephen GrupkeDepartments of Neurosurgery, University of Kentucky, Lexington, KY, United States.
Keith R PennypackerDepartment of Neurology, University of Kentucky, Lexington, KY, United States.
University of Kentucky · USUniversity of Washington · US

Funding

Omics and Symptom Science Training ProgramT32NR016913 · NINR · UNIVERSITY OF WASHINGTON · PI CYNTHIA M DOUGHERTY, Margaret McLean Heitkemper · 2017 to 2026
$3.2M
NINR NIH HHS T32 NR016913
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

chemokinescytokinesgene expressionischemic strokemachine learning

Identifiers

PMID32010048
PMCPMC6974670
OpenAlexW2998879175

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.