ArticleFrontiers in aging neuroscience2019
Aging Disrupts the Circadian Patterns of Protein Expression in the Murine Hippocampus.
Article in Frontiers in aging neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Internal desynchrony of the hepatic circadian system with dissociated systemic rhythms in middle-aged mice under social jet lag-like conditions.Scientific reports · 2026Article
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- Exploring the connection between the Mitochondrial DNA and the Circadian Rhythm: Insights into Mitochondrial Biogenesis and its Dynamics.Molecular biology reports · 2025Review
- Multifaceted dynamics of circadian timing system influence aging and longevity.Biogerontology · 2025Review
- Sleep deprivation leads to non-adaptive alterations in sleep microarchitecture and amyloid-β accumulation in a murine Alzheimer model.Cell reports · 2024Article
- A scenario of unhealthy life cycle: The role of circadian rhythms in health.Aging medicine (Milton (N.S.W)) · 2024Review
- The contribution of circadian clock to the biological processes.Frontiers in molecular biosciences · 2024Review
- Mechanisms of Extraorbital Lacrimal Gland Aging in Mice: An Integrative Analysis of the Temporal Transcriptome.Investigative ophthalmology & visual science · 2023Article
- Defining diurnal fluctuations in mouse choroid plexus and CSF at high molecular, spatial, and temporal resolution.Nature communications · 2023Article
- Association of Circadian Clock Gene Expression with Pediatric/Adolescent Asthma and Its Comorbidities.International journal of molecular sciences · 2023Article
- Myeloid deficiency of the intrinsic clock protein BMAL1 accelerates cognitive aging by disrupting microglial synaptic pruning.Journal of neuroinflammation · 2023Article
- Circadian Rhythm Effects on the Molecular Regulation of Physiological Systems.Comprehensive Physiology · 2021Review
- Regulation of Heme Oxygenase and Its Cross-Talks with Apoptosis and Autophagy under Different Conditions inAntioxidants (Basel, Switzerland) · 2021Article
- Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology.Nature communications · 2021Article
- Chronobiotics KL001 and KS15 Extend Lifespan and Modify Circadian Rhythms ofClocks & sleep · 2021Article
- A multi-level assessment of the bidirectional relationship between aging and the circadian clock.Journal of neurochemistry · 2021Review
- Anti-aging effects of Korean Red Ginseng (KRG) in differentiated embryo chondrocyte (DEC) knockout mice.Journal of ginseng research · 2021Article
- Aging Alters Daily and Regional Calretinin Neuronal Expression in the Rat Non-image Forming Visual Thalamus.Frontiers in aging neuroscience · 2021Article
- Dose-Response Effect of Vibratory Stimulus on Synaptic and Muscle Plasticity in a Middle-Aged Murine Model.Frontiers in physiology · 2021Article
- Steps Towards Developing Effective Treatments for Neuropsychiatric Disturbances in Alzheimer's Disease: Insights From Preclinical Models, Clinical Data, and Future Directions.Frontiers in aging neuroscience · 2020Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging is associated with cognitive decline and dysregulation of the circadian system, which modulates hippocampal-dependent memory as well as biological processes underlying hippocampal function. While circadian dysfunction and memory impairment are common features of aging and several neurodegenerative brain disorders, how aging impacts the circadian expression patterns of proteins involved in processes that underlie hippocampal-dependent memory is not well understood. In this study, we profiled the hippocampal proteomes of young and middle-aged mice across two circadian cycles using quantitative mass spectrometry in order to explore aging-associated changes in the temporal orchestration of biological pathways. Of the ∼1,420 proteins that were accurately quantified, 15% (214 proteins) displayed circadian rhythms in abundance in the hippocampus of young mice, while only 1.6% (23 proteins) were rhythmic in middle-aged mice. Remarkably, aging disrupted the circadian regulation of proteins involved in cellular functions critical for hippocampal function and memory, including dozens of proteins participating in pathways of energy metabolism, neurotransmission, and synaptic plasticity. These included processes such as glycolysis, the tricarboxylic acid cycle, synaptic vesicle cycling, long-term potentiation, and cytoskeletal organization. Moreover, aging altered the daily expression rhythms of proteins implicated in hallmarks of aging and the pathogenesis of several age-related neurodegenerative brain disorders affecting the hippocampus. Notably, we identified age-related alterations in the rhythmicity of proteins involved in mitochondrial dysfunction and loss of proteostasis, as well as proteins involved in the pathogenesis of disorders such as Alzheimer's disease and Parkinson's disease. These insights into aging-induced changes in the hippocampal proteome provide a framework for understanding how the age-dependent circadian decline may contribute to cognitive impairment and the development of neurodegenerative diseases during aging.
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