Evidence map›Paper›PMID 32009920›Full record

ArticleFrontiers in computational neuroscience2019

Network Models Predict That Pyramidal Neuron Hyperexcitability and Synapse Loss in the dlPFC Lead to Age-Related Spatial Working Memory Impairment in Rhesus Monkeys.

Sara Ibañez, Jennifer I Luebke, Wayne Chang, Danel Draguljić, Christina M Weaver

Open access · goldAbstract read
In one paragraph

Article in Frontiers in computational neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sara IbañezDepartment of Mathematics, Franklin and Marshall College, Lancaster, PA, United States.
Jennifer I LuebkeDepartment of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, United States.
Wayne ChangDepartment of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, United States.
Danel DraguljićDepartment of Mathematics, Franklin and Marshall College, Lancaster, PA, United States.
Christina M WeaverDepartment of Mathematics, Franklin and Marshall College, Lancaster, PA, United States.
Boston University · USFranklin & Marshall College · US

Funding

Mechanisms of Age-related Cognitive Decline in the Rhesus MonkeyR01AG059028 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HOF, PATRICK R, LUEBKE, JENNIFER I · 2018 to 2022
$3.5M
Neural substrates of cognitive decline and curcumin intervention in aging monkeysR56AG049870 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HOF, PATRICK R, LUEBKE, JENNIFER I · 2016 to 2016
$751k
NIA NIH HHS R01 AG059028NIA NIH HHS R56 AG049870
6 · The paper itself

Abstract

Behavioral studies have shown spatial working memory impairment with aging in several animal species, including humans. Persistent activity of layer 3 pyramidal dorsolateral prefrontal cortex (dlPFC) neurons during delay periods of working memory tasks is important for encoding memory of the stimulus.

Indexed as

bump attractorpatch clamppersistent activityprefrontal cortexsynaptic plasticity

Identifiers

PMID32009920
PMCPMC6979278
OpenAlexW3000530690

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.