ArticleFrontiers in cellular neuroscience2019
Opposing Somatic and Dendritic Expression of Stimulus-Selective Response Plasticity in Mouse Primary Visual Cortex.
Article in Frontiers in cellular neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Visual experience drives functional reorganization of cortical GABAergic circuits.bioRxiv : the preprint server for biology · 2026Article
- Circuit dynamics of binocular conflict in mouse primary visual cortex.Frontiers in systems neuroscience · 2026Article
- Temporary retinal inactivation reverses effects of long-term monocular deprivation in visual cortex by induction of burst mode firing in the thalamus.Cell reports · 2025Article
- Sleep and experience-dependent visual plasticity in the adult cerebral cortex: an update.Sleep · 2025Article
- Responses to conflicting binocular stimuli in mouse primary visual cortex.bioRxiv : the preprint server for biology · 2025Article
- The visual evoked potential is a sensitive and powerful measure of experience-dependent visual cortical plasticity in mice.Current opinion in neurobiology · 2025Review
- Rapid and cumulative adult plasticity in the mouse visual cortex.Frontiers in neural circuits · 2025Article
- Stimulus-dependent synaptic plasticity underlies neuronal circuitry refinement in the mouse primary visual cortex.Cell reports · 2024Article
- Repeated passive visual experience modulates spontaneous and non-familiar stimuli-evoked neural activity.Scientific reports · 2023Article
- Electrophysiological Signatures of Visual Recognition Memory across All Layers of Mouse V1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Excitation-inhibition imbalance disrupts visual familiarity in amyloid and non-pathology conditions.Cell reports · 2023Article
- Plasticity in visual cortex is disrupted in a mouse model of tauopathy.Communications biology · 2022Article
- Multiple Mechanistically Distinct Timescales of Neocortical Plasticity Occur During Habituation.Frontiers in cellular neuroscience · 2022Article
- The spatiotemporal organization of experience dictates hippocampal involvement in primary visual cortical plasticity.Current biology : CB · 2021Article
- Stimulus-Selective Response Plasticity in Primary Visual Cortex: Progress and Puzzles.Frontiers in neural circuits · 2021Review
- Visual Sequences Drive Experience-Dependent Plasticity in Mouse Anterior Cingulate Cortex.Cell reports · 2020Article
- Reward Association Enhances Stimulus-Specific Representations in Primary Visual Cortex.Current biology : CB · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Daily exposure of awake mice to a phase-reversing visual grating stimulus leads to enhancement of the visual-evoked potential (VEP) in layer 4 of the primary visual cortex (V1). This stimulus-selective response potentiation (SRP) resembles and shares mechanistic requirements with canonical long-term synaptic potentiation (LTP). However, it remains to be determined how this augmentation of a population response translates into altered neuronal activity of individual V1 neurons. To address this question, we performed longitudinal calcium imaging of layer 4 excitatory neurons in V1 and tracked changes associated with the induction and expression of SRP. We found no evidence for a net change in the fraction of visually responsive neurons as the stimulus became familiar. However, endoscopic calcium imaging of layer 4 principal neurons revealed that somatic calcium transients in response to phase-reversals of the familiar visual stimulus are reduced and undergo strong within-session adaptation. Conversely, neuropil calcium responses and VEPs are enhanced during familiar stimulus viewing, and the VEPs show reduced within-session adaptation. Consistent with the exquisite selectivity of SRP, the plasticity of cellular responses to phase-reversing gratings did not translate into altered orientation selectivity to drifting gratings. Our findings suggest a model in which augmentation of fast, short-latency synaptic (dendritic) responses, manifested as enhanced layer 4 VEPs, recruits inhibition to suppress cellular activity. Reduced cellular activity to the familiar stimulus may account for the behavioral correlate of SRP, orientation-selective long-term habituation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.