ArticleFrontiers in neuroscience2019
Patching and Suppression in Amblyopia: One Mechanism or Two?
Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Syntonic phototherapy versus part time occlusion for treatment of refractive amblyopia.Scientific reports · 2025Trial
- Rethinking perceptual distortions in amblyopia: toward a multi-feature, visual-field-wide perspective.Frontiers in neuroscience · 2026Article
- Mitochondria-Mediated Mechanisms of Ferroptosis in Neurological Diseases.Neurochemical research · 2025Review
- The Suppressive Basis of Ocular Dominance Changes Induced by Short-Term Monocular Deprivation in Normal and Amblyopic Adults.Investigative ophthalmology & visual science · 2023Article
- Characterizing amblyopic perception under non-rivalrous viewing conditions.Scientific reports · 2023Article
- Ocular and visual perceptive factors associated with treatment outcomes in patients with anisometropic amblyopia.BMC ophthalmology · 2023Observational
- The Association Between Improvement of Stereoacuity and Suppression in the Treatment of Anisometropic Amblyopia.Clinical ophthalmology (Auckland, N.Z.) · 2023Article
- Visual rehabilitation indicating neuroplasticity in an esotropic adult patient with diplopia after sudden visual acuity loss in the non-amblyopic eye: A case report.NeuroRehabilitation · 2023Article
- The shift in sensory eye dominance from short-term monocular deprivation exhibits no dependence on test spatial frequency.Eye and vision (London, England) · 2022Article
- Modulation of mean luminance improves binocular balance across spatial frequencies in amblyopia.iScience · 2022Article
- Some psychophysical tasks measure ocular dominance plasticity more reliably than others.Journal of vision · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo determine if benefits from occlusion therapy are due to decreased suppression from the fellow eye in children with amblyopia.
methodsTen newly diagnosed amblyopes (7.2 ± 1.4 years old), two with strabismus and eight with anisometropia, participated. Patients were first given a 2-month period of refractive adaptation, followed by occlusion therapy (i.e., patching their fellow eye with an opaque patch for 4 h/day). Visual acuity of the amblyopic eye and interocular suppression were measured before and after 0.5, 1, 2, 4, and 6 months of occlusion therapy. We quantified interocular suppression with a binocular phase combination task.
resultsVisual acuity (in logMAR) improved from 0.50 ± 0.22 (mean ± SD) to 0.33 ± 0.20 for patients who finished a short-term (2 months) occlusion (A1-A10), from 0.53 ± 0.20 to 0.32 ± 0.22 for patients who finished a medium-term (4 months) occlusion (A1-A9), and from 0.48 ± 0.19 to 0.22 ± 0.10 for patients who finished a long-term (6 months) occlusion (A1-A8). Although their visual acuity significantly improved, their degree of suppression, which was abnormal in all cases, did not change consistently. This was true in all durations of occlusion therapy.
conclusionReduced suppression from the fixing eye might not be result from occlusion therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.