Evidence map›Paper›PMID 32009792›Full record

ArticleOncoTargets and therapy2019

The Prognostic Significance Of Pretreatment Albumin/alkaline Phosphatase Ratio In Patients With Stage IB-IIA Cervical Cancer.

Can Zhang, Yong Li, Rui Ji, Weiling Zhang, Chenfei Zhang, Youli Dan, Hongyan Qian, Aiqin He

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in OncoTargets and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. A meta-analysis of albumin, globulin, and albumin globulin ratios for predicting prognosis of cervical cancer.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Can Zhang *Department of Gynecology Oncology, Tumor Hospital Affiliated to Nantong University, Nantong, People's Republic of China.
Yong Li *Department of Gynecology Oncology, Tumor Hospital Affiliated to Nantong University, Nantong, People's Republic of China.ORCID 0000-0003-0005-5266
Rui JiDepartment of Gynecology Oncology, Tumor Hospital Affiliated to Nantong University, Nantong, People's Republic of China.
Weiling ZhangDepartment of Gynecology Oncology, Tumor Hospital Affiliated to Nantong University, Nantong, People's Republic of China.
Chenfei ZhangDepartment of Medical Oncology, Tumor Hospital Affiliated to Nantong University, Nantong, People's Republic of China.
Youli DanDepartment of Oncology, Medical College of Nantong University, Nantong, People's Republic of China.
Hongyan QianCancer Research Centre Nantong, Tumor Hospital Affiliated to Nantong University, Nantong, People's Republic of China.ORCID 0000-0001-9531-1431
Aiqin HeDepartment of Gynecology Oncology, Tumor Hospital Affiliated to Nantong University, Nantong, People's Republic of China.
Nantong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPretreatment albumin/alkaline phosphatase ratio (AAPR) has been discussed about its prognostic value in several malignancies, whereas its role in cervical cancer remains unclear. In this study, we attempt to explore the prognostic significance of the AAPR in stage IB-IIA cervical cancer patients who underwent a radical hysterectomy. PATIENTS AND

methodsA total of 230 cervical cancer patients were enrolled in this retrospective study. The threshold value of AAPR was determined by receiver operating characteristic (ROC) curve. Kaplan-Meier survival analysis and multivariate analysis were performed to identify independent prognostic predictors of disease-free survival (DFS) and overall survival (OS).

resultsThe optimal cut-off value of the preoperative AAPR was 0.68. Patients with AAPR<0.68 showed obviously inferior OS and DFS than those with AAPR>0.68 according to Kaplan-Meier curves (DFS: P = 0.011; OS: P = 0.017). In multivariate analysis, the preoperative AAPR showed to be an independent predictive factor for disease-free survival (DFS: P = 0.015) and overall survival (OS: P = 0.019). Moreover, subgroup analysis revealed that the lower AAPR was correlated with worse prognosis in patients with histologic grade I-II; but in those with histologic grade III, there was no significant difference between the two groups.

conclusionPreoperative AAPR was a potentially valuable prognostic index in stage IB-IIA cervical cancer patients. Further prospective studies are required to validate its prognostic value.

Indexed as

albumin-to-alkaline phosphatase ratioprognosissurvival analysisuterine cervical neoplasms

Identifiers

PMID32009792
PMCPMC6859168
OpenAlexW2985483711

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.