Evidence map›Paper›PMID 32009536›Full record

ArticleRNA biology2020

Regulation of the Ysh1 endonuclease of the mRNA cleavage/polyadenylation complex by ubiquitin-mediated degradation.

Susan D Lee, Hui-Yun Liu, Joel H Graber, Daniel Heller-Trulli, Katarzyna Kaczmarek Michaels, Juan Francisco Cerezo, Claire L Moore

Open access · bronzeAbstract read
In one paragraph

Article in RNA biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Susan D LeeDepartment of Developmental, Molecular, and Chemical Biology and Tufts School of Graduate Biomedical Science, Tufts University School of Medicine, Boston, MA, USA.
Hui-Yun LiuDepartment of Developmental, Molecular, and Chemical Biology and Tufts School of Graduate Biomedical Science, Tufts University School of Medicine, Boston, MA, USA.
Joel H GraberComputational Biology and Bioinformatics Core, Mount Desert Island Biological Laboratory, Bar Harbor, ME, USA.ORCID 0000-0001-5137-4553
Daniel Heller-TrulliDepartment of Developmental, Molecular, and Chemical Biology and Tufts School of Graduate Biomedical Science, Tufts University School of Medicine, Boston, MA, USA.ORCID 0000-0003-0549-0646
Katarzyna Kaczmarek MichaelsDepartment of Developmental, Molecular, and Chemical Biology and Tufts School of Graduate Biomedical Science, Tufts University School of Medicine, Boston, MA, USA.ORCID 0000-0002-2525-5830
Juan Francisco CerezoExperimental Sciences, Universidad Francisco de Vitoria, Madrid, Spain.
Claire L MooreDepartment of Developmental, Molecular, and Chemical Biology and Tufts School of Graduate Biomedical Science, Tufts University School of Medicine, Boston, MA, USA.ORCID 0000-0002-1883-9459
Tufts University · USMount Desert Island Biological Laboratory · USUniversidad Francisco de Vitoria · ES

Funding

The Maine Biomedical Research Network (INBRE)P20GM103423 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI Dustin Lynn Updike · 2012 to 2026
$60.0M
Understanding the role of thyroid hormone signaling during axolotl limb regenerationP20GM104318 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI DRUMMOND, IAIN A. · 2013 to 2023
$23.0M
NIGMS NIH HHS P20 GM103423NIGMS NIH HHS P20 GM104318
6 · The paper itself

Abstract

Mutation of the essential yeast protein Ipa1 has previously been demonstrated to cause defects in pre-mRNA 3' end processing and growth, but the mechanism underlying these defects was not clear. In this study, we show that the

Indexed as

Gene Expression RegulationEndonucleasesmRNA Cleavage and Polyadenylation FactorsMultiprotein ComplexesProteasome Endopeptidase ComplexProtein BindingRNA, MessengerRNA StabilityUbiquitinUbiquitin-Conjugating EnzymesEndonucleasesmRNA Cleavage and Polyadenylation FactorsMultiprotein ComplexesProteasome Endopeptidase ComplexRNA, MessengerUbiquitinUbiquitin-Conjugating Enzymesubiquitin-conjugating enzyme UBC4alternative mRNA processingPolyadenylationubiquitination

Identifiers

PMID32009536
PMCPMC7237158
OpenAlexW3005322528

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.