Evidence map›Paper›PMID 32009528›Full record

ArticleJournal of the American Heart Association2020

Vascular Endothelial Growth Factor-121 Administration Mitigates Halogen Inhalation-Induced Pulmonary Injury and Fetal Growth Restriction in Pregnant Mice.

Dylan R Addis, James A Lambert, Changchun Ren, Stephen Doran, Saurabh Aggarwal, Tamas Jilling, Sadis Matalon

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Halogen gas exposure: toxic effects on the parturient.Toxicology mechanisms and methods · 2021
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Dylan R AddisDivision of Cardiothoracic Anesthesiology Department of Anesthesiology and Perioperative Medicine University of Alabama at Birmingham Birmingham AL USA.
James A LambertDivision of Molecular and Translational Biomedicine Department of Anesthesiology and Perioperative Medicine University of Alabama at Birmingham Birmingham AL USA.
Changchun RenDepartment of Pediatrics Division of Neonatology University of Alabama at Birmingham Birmingham AL USA.
Stephen DoranDivision of Molecular and Translational Biomedicine Department of Anesthesiology and Perioperative Medicine University of Alabama at Birmingham Birmingham AL USA.
Saurabh AggarwalDivision of Molecular and Translational Biomedicine Department of Anesthesiology and Perioperative Medicine University of Alabama at Birmingham Birmingham AL USA.
Tamas JillingDepartment of Pediatrics Division of Neonatology University of Alabama at Birmingham Birmingham AL USA.
Sadis MatalonDivision of Molecular and Translational Biomedicine Department of Anesthesiology and Perioperative Medicine University of Alabama at Birmingham Birmingham AL USA.
University of Alabama at Birmingham · USComprehensive Cardiovascular · US

Funding

Nitrite dependent protection against Cl2 gas toxicity_role of chlorinated lipidsU01ES023759 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PATEL, RAKESH P. · 2013 to 2018
$3.9M
Bromine Inhalation Induced Lung Injury: Novel Mechanisms and Treatment StrategiesU01ES026458 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MATALON, SADIS · 2015 to 2019
$3.9M
CIALIS® reverses halogen induced injury to pregnant animals and their offspringU01ES027697 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JILLING, TAMAS SANDOR, MATALON, SADIS · 2016 to 2020
$3.7M
Training Program in Cardiovascular PathophysiologyT32HL007918 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BALLINGER, SCOTT W. · 1999 to 2018
$3.6M
Basic and Translational Science in Heart FailureT32HL129948 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YOUNG, MARTIN E · 2017 to 2021
$1.4M
NHLBI NIH HHS T32 HL007918NHLBI NIH HHS T32 HL129948NIEHS NIH HHS U01 ES023759NIEHS NIH HHS U01 ES026458NIEHS NIH HHS U01 ES027697
6 · The paper itself

Abstract

Background Circulating levels of sFLT-1 (soluble fms-like tyrosine kinase 1), the extracellular domain of vascular endothelial growth factor (VEGF) receptor 1, and its ratio to levels of placental growth factor are markers of the occurrence and severity of preeclampsia. Methods and Results C57BL/6 pregnant mice on embryonic day 14.5 (E14.5), male, and non-pregnant female mice were exposed to air or to Br

Indexed as

AnimalsBromineDisease Models, AnimalFemaleFetal DevelopmentFetal Growth RetardationInjections, SubcutaneousLungMice, Inbred C57BLPlacentaPlacentationPregnancyPulmonary EdemaSignal TransductionVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1BromineFlt1 protein, mouseVascular Endothelial Growth Factor Avascular endothelial growth factor A, mouseVascular Endothelial Growth Factor Receptor-1hemodynamicslung edemapreeclampsiapregnancyvascular biology

Identifiers

PMID32009528
PMCPMC7033856
OpenAlexW3005344650

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.