SynthesisNeurologia medico-chirurgica2020
Natural History of Meningiomas: Review with Meta-analyses.
Synthesis in Neurologia medico-chirurgica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- From data to practice: brain meningioma treatment in elderly patients - a survey of the Italian Society of Neurosurgery (SINch®) and systematic review and meta-analysis.Neurosurgical review · 2024Pooled it
- Biphasic growth and subsequent spontaneous regression of posterior fossa meningioma with progressive calcification: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Article
- Survival Outcomes and Prognostic Factors in Patients with Meningioma: A Single-Center Study at the Indonesian National Cancer Center Dharmais Hospital (2019-2025).Current oncology (Toronto, Ont.) · 2026Article
- Spontaneous Regression of Meningiomas: Literature Review and Case Report.Asian journal of neurosurgery · 2026Article
- Article
- Spontaneous Regression of Incidental Meningioma in the Posterior Cranial Fossa: A Case Report and Literature Review.Brain tumor research and treatment · 2025Article
- Medical Management of a Meningioma Presenting as an Ischemic Stroke: A Case Report and Review of the Literature.Cureus · 2025Article
- Multicenter evaluation of preoperative and standalone embolization in meningiomas.Frontiers in oncology · 2025Article
- Exploring the role of volumetric and radiological features in meningioma behaviour and follow-up strategies.Brain & spine · 2025Article
- Radiosurgery for Intracranial Meningiomas: A Review of Anatomical Challenges and an Update on the Evidence.Cancers · 2024Review
- Automated volumetry of meningiomas in contrast-enhanced T1-Weighted MRI using deep learning.World neurosurgery: X · 2024Article
- The management of incidental meningioma: An unresolved clinical conundrum.Neuro-oncology advances · 2023Article
- Meningioma in the elderly.Neuro-oncology advances · 2023Article
- Surgical Therapy of Non-Skull Base Meningiomas.Advances in experimental medicine and biology · 2023Article
- Review
- Meningioma With Partial and Spontaneous Regression of Peritumoral Edema on Long-Term Follow Up.Brain tumor research and treatment · 2022Article
- Histopathological Investigation of Meningioma Capsule with Respect to Tumor Cell Invasion.Neurologia medico-chirurgica · 2022Article
- Stereotactic radiosurgery versus active surveillance for incidental, convexity meningiomas: a matched cohort analysis from the IMPASSE study.Journal of neuro-oncology · 2022Article
- Outcomes of Preserving the Hypertrophic Arachnoid Membrane in the Brain-meningioma Interface: Long-term Follow-up.Neurologia medico-chirurgica · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Observation has been a mainstay in asymptomatic meningiomas, but it may increase the risk associated with treatment due to tumor enlargement and the aging of patients. Understanding the natural course of meningiomas is important to provide appropriate treatment. The majority of previous studies investigated factors related to their growth, but failed to demonstrate their relationship with symptomatic progression (sympP) because of its rarity. We reviewed and meta-analyzed 27 studies that investigated natural courses in asymptomatic or untreated meningiomas to find clinico-radiological factors predictive of radiological progression (radioP), growth speed, and sympP. In results of time-growth analysis, two-thirds of meningiomas showed radioP defined by a volume criterion and the rate approached a plateau at 4-5 years. In growth curve analyses, about half of incidental meningiomas presented decelerating or no growth, while less than one-quarter of them grew exponentially. RadioP, growth speed [annual volume change (AVC) or relative growth rate], and sympP each had different factors related to them. Younger age, non-calcification, and high intensity on T2-weighted image were related to radioP and rapid growth speed, but not to sympP. Tumors in males and those of larger size were likely to be symptomatic in the meta-analysis. AVC (≥2.1 cm
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