ArticleMedical engineering & physics2020
A novel 3D-Printed preferential posterior mitral annular dilation device delineates regurgitation onset threshold in an ex vivo heart simulator.
Article in Medical engineering & physics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 21 citations in OpenAlex.
- Design and evaluation of valve interventions using ex vivo biomechanical modeling: the Stanford experience.General thoracic and cardiovascular surgery · 2025Review
- Repairable ex vivo model of functional and degenerative mitral regurgitation.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2023Article
- Chordal force profile after neochordal repair of anterior mitral valve prolapse: An ex vivo study.JTCVS open · 2023Article
- A Novel Rheumatic Mitral Valve Disease Model with Ex Vivo Hemodynamic and Biomechanical Validation.Cardiovascular engineering and technology · 2023Article
- Artificial papillary muscle device for off-pump transapical mitral valve repair.The Journal of thoracic and cardiovascular surgery · 2022Article
- DynaRing: A Patient-Specific Mitral Annuloplasty Ring With Selective Stiffness Segments.Journal of medical devices · 2022Article
- Image-Guided Targeted Mitral Valve Tethering with Chordal Encircling Snares as a Preclinical Model of Secondary Mitral Regurgitation.Journal of cardiovascular translational research · 2022Article
- Biomechanical engineering analysis of an acute papillary muscle rupture disease model using an innovative 3D-printed left heart simulator.Interactive cardiovascular and thoracic surgery · 2022Article
- Efficacy of a Novel Posterior Leaflet Repair Device to Treat Secondary Mitral Regurgitation Using an Ex Vivo Heart Model.Structural heart : the journal of the Heart Team · 2022Article
- Ex vivo biomechanical analysis of flexible versus rigid annuloplasty rings in mitral valves using a novel annular dilation system.BMC cardiovascular disorders · 2022Article
- Commentary: Valvular mimicry in simulation-espice, adspice, prospice.The Journal of thoracic and cardiovascular surgery · 2022Article
- Novel bicuspid aortic valve model with aortic regurgitation for hemodynamic status analysis using an ex vivo simulator.The Journal of thoracic and cardiovascular surgery · 2022Article
- Mitral Valve-in-Valve Implant of a Balloon-Expandable Valve Guided by 3-Dimensional Printing.Frontiers in cardiovascular medicine · 2022Article
- Ex Vivo Model of Ischemic Mitral Regurgitation and Analysis of Adjunctive Papillary Muscle Repair.Annals of biomedical engineering · 2021Article
- Biomechanical engineering comparison of four leaflet repair techniques for mitral regurgitation using a novel 3-dimensional-printed left heart simulator.JTCVS techniques · 2021Article
- Novel device prototyping for endoscopic cell sheet transplantation using a three-dimensional printed simulator.Regenerative therapy · 2020Article
- Biomimetic six-axis robots replicate human cardiac papillary muscle motion: pioneering the next generation of biomechanical heart simulator technology.Journal of the Royal Society, Interface · 2020Article
- Article
- In Vivo Validation of Restored Chordal Biomechanics After Mitral Ring Annuloplasty in a Rare Ovine Case of Natural Chronic Functional Mitral Regurgitation.Journal of cardiovascular development and disease · 2020Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Mitral regurgitation (MR) due to annular dilation occurs in a variety of mitral valve diseases and is observed in many patients with heart failure due to mitral regurgitation. To understand the biomechanics of MR and ultimately design an optimized annuloplasty ring, a representative disease model with asymmetric dilation of the mitral annulus is needed. This work shows the design and implementation of a 3D-printed valve dilation device to preferentially dilate the posterior mitral valve annulus. Porcine mitral valves (n = 3) were sewn into the device and mounted within a left heart simulator that generates physiologic pressures and flows through the valves, while chordal forces were measured. The valves were incrementally dilated, inducing MR, while hemodynamic and force data were collected. Flow analysis demonstrated that MR increased linearly with respect to percent annular dilation when dilation was greater than a 25.6% dilation threshold (p < 0.01). Pre-threshold, dilation did not cause significant increases in regurgitant fraction. Forces on the chordae tendineae increased as dilation increased prior to the identified threshold (p < 0.01); post-threshold, the MR resulted in highly variable forces. Ultimately, this novel dilation device can be used to more accurately model a wide range of MR disease states and their corresponding repair techniques using ex vivo experimentation. In particular, this annular dilation device provides the means to investigate the design and optimization of novel annuloplasty rings.
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