Evidence map›Paper›PMID 32008895›Full record

ReviewTrends in cell biology2020

Getting into Position: Nuclear Movement in Muscle Cells.

Mafalda Azevedo, Mary K Baylies

Open access · greenAbstract readReview
In one paragraph

Review in Trends in cell biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 47 citations in OpenAlex.

  1. Motor-Assisted Co-Migration of Intracellular Organelles and Microtubules as a Mechanism for Directed Cargo Transport.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Myotube Guidance: Shaping up the Musculoskeletal System.Journal of developmental biology · 2024
    Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Mechanics and functional consequences of nuclear deformations.Nature reviews. Molecular cell biology · 2022
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Mafalda AzevedoProgram in Developmental Biology, Sloan Kettering Institute, New York, NY, USA; Graduate Program in Areas of Basic and Applied Biology (GABBA), Abel Salazar Biomedical Sciences Institute, University of Porto, Porto, Portugal.
Mary K BayliesProgram in Developmental Biology, Sloan Kettering Institute, New York, NY, USA; Cell and Developmental Biology, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY, USA. Electronic address: m-baylies@ski.mskcc.org.
Cornell University · USUniversidade do Porto · PT

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Mechanisms and Function of Myonuclear PositioningR01AR068128 · NIAMS · SLOAN-KETTERING INST CAN RESEARCH · PI BAYLIES, MARY K · 2014 to 2025
$5.1M
Mechanisms Regulating Myoblast Fusion in DrosophilaR01GM078318 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI BAYLIES, MARY K · 2007 to 2010
$2.0M
Sizing and Scaling in Functional Muscle CellsR01GM121971 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI BAYLIES, MARY K · 2017 to 2020
$1.8M
NCI NIH HHS P30 CA008748NIAMS NIH HHS R01 AR068128NIGMS NIH HHS R01 GM078318NIGMS NIH HHS R01 GM121971
6 · The paper itself

Abstract

The positioning of nuclei within the cell is a dynamic process that depends on the cell's fate and developmental stage and that is adjusted for optimal cell function. This is especially true in skeletal muscle cells, which contain hundreds of myonuclei distributed evenly along the periphery of the muscle cell. Mispositioned myonuclei are often associated with muscle dysfunction and disease. Different mechanisms governing myonuclear positioning are now emerging, with several of the new genes implicated in nuclear movement linked to human muscle disease. Here we discuss the recent advances in myonuclear positioning and its implications for muscle size and function from the view of Drosophila. Additionally, we highlight similarities and differences to mammalian systems and provide connections to human muscle disease.

Indexed as

AnimalsCell NucleusDrosophila melanogasterHumansMovementMuscle CellsMuscle, SkeletalcytoskeletonDrosophilaLINC complexmusclemuscle diseasenuclear positioning

Identifiers

PMID32008895
PMCPMC7131867
OpenAlexW3003744260

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.