ArticleThe Journal of pediatrics2020
Behavior Profiles at 2 Years for Children Born Extremely Preterm with Bronchopulmonary Dysplasia.
Article in The Journal of pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- The association between bronchopulmonary dysplasia severity and neurodevelopmental disorders.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Neuroprognostication in infants born preterm at the limits of viability: assessment under uncertainty.Pediatric research · 2026Review
- Early-life lung injury and the developing brain: a lung-brain axis perspective on neurodevelopmental disorders.Journal of neuroinflammation · 2026Review
- Parents' Perceptions of Delays and Disabilities in Their Children Requiring Invasive Mechanical Ventilation.Pediatric pulmonology · 2026Article
- Association ofBiomedicines · 2025Article
- Outcomes of extremely preterm infants with bronchopulmonary dysplasia: a retrospective cohort study.Scientific reports · 2025Article
- Increased bronchopulmonary dysplasia along with decreased mortality in extremely preterm infants.Scientific reports · 2025Article
- Caffeine: The Story beyond Oxygen-Induced Lung and Brain Injury in Neonatal Animal Models-A Narrative Review.Antioxidants (Basel, Switzerland) · 2024Review
- Optimizing trajectories of social adaptive competencies after extreme prematurity during the first 1000 days.Seminars in fetal & neonatal medicine · 2024Review
- Required biological time for lung maturation and duration of invasive ventilation: a Korean cohort study of very low birth weight infants.Frontiers in pediatrics · 2023Article
- Early neurodevelopmental follow-up in the NICHD neonatal research network: Advancing neonatal care and outcomes, opportunities for the future.Seminars in perinatology · 2022Article
- Contributions of the NICHD neonatal research network to the diagnosis, prevention, and treatment of bronchopulmonary dysplasia.Seminars in perinatology · 2022Review
- Neonatal sepsis is associated with behavioral abnormalities in very low birthweight infants at preschool age.Frontiers in pediatrics · 2022Article
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Authors and funding
17 authors at 9 institutions in 1 country.
Funding
Abstract
objectiveTo characterize behavior of 2-year-old children based on the severity of bronchopulmonary dysplasia (BPD). STUDY
designWe studied children born at 22-26 weeks of gestation and assessed at 22-26 months of corrected age with the Child Behavior Checklist (CBCL). BPD was classified by the level of respiratory support at 36 weeks of postmenstrual age. CBCL syndrome scales were the primary outcomes. The relationship between BPD grade and behavior was evaluated, adjusting for perinatal confounders. Mediation analysis was performed to evaluate whether cognitive, language, or motor skills mediated the effect of BPD grade on behavior.
resultsOf 2310 children, 1208 (52%) had no BPD, 806 (35%) had grade 1 BPD, 177 (8%) had grade 2 BPD, and 119 (5%) had grade 3 BPD. Withdrawn behavior (P < .001) and pervasive developmental problems (P < .001) increased with worsening BPD grade. Sleep problems (P = .008) and aggressive behavior (P = .023) decreased with worsening BPD grade. Children with grade 3 BPD scored 2 points worse for withdrawn behavior and pervasive developmental problems and 2 points better for externalizing problems, sleep problems, and aggressive behavior than children without BPD. Cognitive, language, and motor skills mediated the effect of BPD grade on the attention problems, emotionally reactive, somatic complaints, and withdrawn CBCL syndrome scales (P values < .05).
conclusionsBPD grade was associated with increased risk of withdrawn behavior and pervasive developmental problems but with decreased risk of sleep problems and aggressive behavior. The relationship between BPD and behavior is complex. Cognitive, language, and motor skills mediate the effects of BPD grade on some problem behaviors.
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