Evidence map›Paper›PMID 32008666›Full record

ReviewObstetrics and gynecology clinics of North America2020

Evidence for Corpus Luteal and Endometrial Origins of Adverse Pregnancy Outcomes in Women Conceiving with or Without Assisted Reproduction.

Kirk P Conrad

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Obstetrics and gynecology clinics of North America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Article
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  6. Review
  7. Article
  8. Signaling via retinoic acid receptors mediates decidual angiogenesis in mice and human stromal cell decidualization.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
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  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Kirk P ConradDepartment of Physiology and Functional Genomics, D.H. Barron Reproductive and Perinatal Biology Research Program, University of Florida College of Medicine, 1600 Southwest Archer RD, PO Box 100274, M552, Gainesville, FL 32610-0274, USA; Department of Obstetrics and Gynecology, University of Florida College of Medicine, 1600 Southwest Archer RD, PO Box 100294, N3-9, Gainesville, FL 32610-0274, USA. Electronic address: kpconrad@ufl.edu.
Florida College · US

Funding

Mechanisms & Consequences of Vascular Adaptations in Pregnancies Conceived by ARTP01HD065647 · NICHD · UNIVERSITY OF FLORIDA · PI CONRAD, KIRK P · 2011 to 2016
$6.1M
NICHD NIH HHS P01 HD065647
6 · The paper itself

Abstract

Preeclampsia may arise from impaired decidualization in some women. Transcriptomics of mid-secretory biopsy endometrial stromal cells decidualized in vitro and of early gestation choriodecidua from women who experienced preeclampsia with severe features overlapped significantly with the classical endometrial disorders giving rise to the concept of "endometrium spectrum disorders". That is, recurrent implantation failure and miscarriage, endometriosis, normotensive intrauterine growth restriction, preeclampsia and preterm birth may all lie on a continuum of decidual dysregulation, in which phenotypic expression is determined by the specific molecular pathway(s) disrupted and severity of disruption. Women conceiving by programmed IVF protocols showed widespread dysregulation of cardiovascular function and increased rates of adverse pregnancy outcomes including preeclampsia. Programmed cycles preclude development of a corpus luteum (CL), a major regulator of endometrial function. Lack of circulating CL product(s) that are not replaced in programmed cycles (eg, relaxin) could adversely impact the maternal cardiovascular system directly and/or compromise decidualization, thereby increasing preeclampsia risk.

Indexed as

Corpus LuteumEmbryo ImplantationEndometriumFemaleFetal Growth RetardationHumansPregnancyPregnancy OutcomeAutologous frozen embryo transferDeciduaEndometrium spectrum disordersIn vitro fertilizationPreeclampsiaRelaxinTrophoblast

Identifiers

PMID32008666
PMCPMC7106658
OpenAlexW3003543266

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.