Evidence map›Paper›PMID 32008442›Full record

ReviewStem cells and development2020

Stem Cells for Improving the Treatment of Neurodevelopmental Disorders.

Jennifer J Donegan, Daniel J Lodge

Open access · greenAbstract readReview
In one paragraph

Review in Stem cells and development, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jennifer J DoneganDepartment of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Daniel J LodgeDepartment of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
The University of Texas Health Science Center at San Antonio · US

Funding

Regulation of ventral hippocampal system functionR01MH090067 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LODGE, DANIEL · 2010 to 2019
$3.5M
NRSA Training Core (TL1)TL1TR002647 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CHUN, YONG-HEE PATRICIA, FREI, CHRISTOPHER R. · 2018 to 2022
$1.8M
Interneurons differentially regulate discrete pathways from ventral hippocampusR00MH121355 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI DONEGAN, JENNIFER · 2021 to 2023
$825k
Interneurons differentially regulate discrete pathways from ventral hippocampusK99MH121355 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DONEGAN, JENNIFER · 2019 to 2020
$239k
NCATS NIH HHS TL1 TR002647NIMH NIH HHS K99 MH121355NIMH NIH HHS R00 MH121355NIMH NIH HHS R01 MH090067
6 · The paper itself

Abstract

Treatment options for neurodevelopmental disorders such as schizophrenia and autism are currently limited. Antipsychotics used to treat schizophrenia are not effective for all patients, do not target all symptoms of the disease, and have serious adverse side effects. There are currently no FDA-approved drugs to treat the core symptoms of autism. In an effort to develop new and more effective treatment strategies, stem cell technologies have been used to reprogram adult somatic cells into induced pluripotent stem cells, which can be differentiated into neuronal cells and even three-dimensional brain organoids. This new technology has the potential to elucidate the complex mechanisms that underlie neurodevelopmental disorders, offer more relevant platforms for drug discovery and personalized medicine, and may even be used to treat the disease.

Indexed as

Stem Cell TransplantationAnimalsDrug DiscoveryHumansModels, BiologicalNeurodevelopmental DisordersPrecision MedicineStem CellsautismIPSCneuronsorganoidsschizophrenia

Identifiers

PMID32008442
PMCPMC7469694
OpenAlexW3004225066

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.