Evidence map›Paper›PMID 32008204›Full record

ArticleInternational urology and nephrology2020

High-sensitivity Troponin I Predicts Galectin-3 in Chronic Kidney Disease Patients.

Gek Cher Chan, Peh Joo Ho, Jialiang Li, Evan Jon Choon Lee, Horng Ruey Chua, Titus Lau, Sunil Sethi, Boon Wee Teo

Abstract read
PubMed Publisher
In one paragraph

Article in International urology and nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Galectin-3: action and clinical utility in chronic kidney disease.International urology and nephrology · 2024
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Gek Cher ChanDivision of Nephrology, Department of Medicine, National University Hospital, Singapore, Singapore. gek_cher_chan@nuhs.edu.sg.ORCID http://orcid.org/0000-0002-4661-3350
Peh Joo HoHuman Genetics, Genome Institute of Singapore, Singapore, Singapore.
Jialiang LiDepartment of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore.
Evan Jon Choon LeeDivision of Nephrology, Department of Medicine, National University Hospital, Singapore, Singapore.
Horng Ruey ChuaDivision of Nephrology, Department of Medicine, National University Hospital, Singapore, Singapore.
Titus LauDivision of Nephrology, Department of Medicine, National University Hospital, Singapore, Singapore.
Sunil SethiYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Boon Wee TeoDivision of Nephrology, Department of Medicine, National University Hospital, Singapore, Singapore.
National University of Singapore · SGNational University Hospital · SGGenome Institute of Singapore · SG

Funding

Ministry of Education Academic Research Fund Tier 1 2008National Kidney Foundation Singapore NKFRC/2011/07/21National Medical Research Council BlockvoteNational University Health System Clinician Scientist Program-Residency 2014
6 · The paper itself

Abstract

purposePlasma galectin-3 (pG3) regulates inflammation. B-type natriuretic peptide (BNP), high-sensitivity Troponin I (hsTnI), and pG3 concentrations are elevated in chronic kidney disease (CKD) patients. The associations of pG3 with hsTnI/BNP are unclear. We explored the relationship of hsTnI and BNP with pG3 in Asian CKD patients and healthy controls.

methodsWe retrieved prospectively collected frozen plasma samples from 163 stable CKD patients and 105 healthy controls. BNP, hsTnI and pG3 were assayed. pG3 was assessed for associations with age, gender, ethnicity, blood pressures; height, weight, body mass index (BMI), previously diagnosed CKD, diabetes, hypertension, coronary artery disease, estimated glomerular filtration rate (eGFR); C-reactive protein, beta-trace protein, 24 h urine protein, serum albumin, uric acid and cystatin C. We created two models predicting pG3 using multiple linear regression. Akaike Information Criterion (AIC) was used for comparison. Significance was taken at P < 0.05.

resultsCKD versus healthy participants: mean BMI (28.2 vs. 24.9 kg/m

conclusionBNP and hsTnI are associated with pG3 in Asian CKD patients. hsTnI is a better predictor of pG3.

Indexed as

Renal Insufficiency, ChronicBiomarkersBlood ProteinsCardiometabolic Risk FactorsCorrelation of DataFemaleGalectin 3GalectinsHumansMaleMiddle AgedNatriuretic Peptide, BrainPredictive Value of TestsSingaporeTroponin TBiomarkersBlood ProteinsGalectin 3GalectinsLGALS3 protein, humanNatriuretic Peptide, BrainTroponin TAsian ancestryBrainChronic renal failureGalectin-3Natriuretic peptideTroponin I

Identifiers

PMID32008204
OpenAlexW3003494150

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.