ArticleEuropean child & adolescent psychiatry2020
Can auditory warning signals normalize eye movements in children with ADHD?
Article in European child & adolescent psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Transdiagnostic eye-tracking biomarkers of inattention across psychiatric disorders: a systematic review.BMC psychiatry · 2025Pooled it
- Quiet eye training-based intervention can ameliorate inhibitory control but not visuospatial working memory in children with ADHD.Brain and behavior · 2023Trial
- Eye Behaviour in a Targeting Task in Children with ADHD: Linkage to a Level of Attention.Bioengineering (Basel, Switzerland) · 2025Article
- Challenges with shifting, regardless of disengagement: attention mechanisms and eye movements in Williams syndrome.Journal of neurodevelopmental disorders · 2025Article
- Disrupted Attention to Other's Eyes is Linked to Symptoms of ADHD in Childhood.Child psychiatry and human development · 2023Article
- Williams syndrome: reduced orienting to other's eyes in a hypersocial phenotype.Journal of autism and developmental disorders · 2023Article
- Eye-movement indices of arousal predict ADHD and comorbid externalizing symptoms over a 2-year period.Scientific reports · 2023Article
- Attentional Engagement and Disengagement Differences for Circumscribed Interest Objects in Young Chinese Children with Autism.Brain sciences · 2022Article
- Links between Daytime Napping, Night-Time Sleep Quality and Infant Attention: An Eye-Tracking, Actigraphy and Parent-Report Study.Children (Basel, Switzerland) · 2022Article
- Visual search in neurodevelopmental disorders: evidence towards a continuum of impairment.European child & adolescent psychiatry · 2022Article
- Pupil dilation predicts individual self-regulation success across domains.Scientific reports · 2021Article
- Equivalent Behavioral Facilitation to Tactile Cues in Children with Autism Spectrum Disorder.Brain sciences · 2021Article
- The Association between Low Blood Pressure and Attention-Deficit Hyperactivity Disorder (ADHD) Observed in Children/Adolescents Does Not Persist into Young Adulthood. A Population-Based Ten-Year Follow-Up Study.International journal of environmental research and public health · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Attenuated baseline arousal has been hypothesized to underlie symptoms of attention deficit/hyperactivity disorder (ADHD). A behavioral signature of reduced baseline arousal is an increased beneficiary effect of warning signals in reaction tasks. This paradoxical effect is believed to be caused by a temporary increase in arousal induced by warning signals. In a preregistered study, we tested the hypothesis that children with high levels of ADHD symptoms would be hyperresponsive to warning signals in a well-established visual attention task (the gap/overlap paradigm). Previous studies using this task have found slower and more variable saccadic reaction times in children with ADHD compared to typically developing children, suggesting that these eye movement metrics are candidate biomarkers. We examined 71 children, of which 1/3 had a diagnosis of ADHD, using both dimensional analyses and group comparisons. Previously reported findings of reduced saccadic latency and increased latency variability were replicated. Importantly, saccadic latency was normalized by auditory warning signals. Analyses of pupil dilation, a physiological index of arousal and locus coeruleus-noradrenergic activity, confirmed that warning signals led to enhanced arousal. Our findings are novel and contribute to our understanding of arousal and attention in ADHD and have implications for treatment and interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.