ArticleJournal of neural transmission (Vienna, Austria : 1996)2020
Different response to instrumental tests in relation to cognitive demand after dopaminergic stimulation in previously treated patients with Parkinson's disease.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Medication only improves limb movements while deep brain stimulation improves eye and limb movements during visually-guided reaching in Parkinson's disease.Frontiers in human neuroscience · 2023Article
- Complex motion series performance differs between previously untreated patients with Parkinson's disease and controls.Journal of neural transmission (Vienna, Austria : 1996) · 2022Article
- Program of Seven 45-min Dry Immersion Sessions Improves Choice Reaction Time in Parkinson's Disease.Frontiers in physiology · 2020Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Instrumental measurement of response assets and movement behaviour gained importance as addition to rating procedures to determine the efficacy of therapeutic interventions in patients with Parkinson's disease. Objectives were to determine the response to standardised 100 mg levodopa application with repeat performance of complex and simple instrumental tests in relation to scored motor behaviour in 53 previously treated patients. Levodopa improved rating scores of motor impairment, execution of complicated movement patterns and complex reaction time. Computed improvements in these instrumental test results correlated with each other. Execution of the simple reaction time paradigm and of plain movement sequences did not ameliorate after levodopa. The changes of these simple test results were not associated to each other. These different response patterns result from the higher cognitive demand of dopamine sensitive association areas of the prefrontal cortex and mesolimbic system for the complex test execution in contrast to the simple task performance.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.