ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2020
Ictal and interictal source imaging on intracranial EEG predicts epilepsy surgery outcome in children with focal cortical dysplasia.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Digital Twins and Health Care: an Umbrella Review.Journal of medical systems · 2025Pooled it
- Assessing the benefits of digital twins in neurosurgery: a systematic review.Neurosurgical review · 2024Pooled it
- How to Recognize and Manage Missing Key Electrodes in Defining the Epileptogenic Zone.Epilepsy currents · 2026Article
- 3D printed pediatric head phantom for assessing deep epileptic sources localization.Computers in biology and medicine · 2026Article
- Stereo-EEG propagating source reconstruction identifies new surgical targets for epilepsy patients.Brain : a journal of neurology · 2025Article
- Machine learning on interictal intracranial EEG predicts surgical outcome in drug resistant epilepsy.NPJ digital medicine · 2025Article
- Medical Digital Twin: A Review on Technical Principles and Clinical Applications.Journal of clinical medicine · 2025Review
- Transcranial 1064-nm laser photobiomodulation modulates frequency-specific cortical source dynamics and functional connectivity in healthy adults.Frontiers in human neuroscience · 2025Article
- A spatial perturbation framework to validate implantation of the epileptogenic zone.Nature communications · 2024Article
- Electrical Source Imaging of Somatosensory Evoked Potentials from Intracranial EEG Signals.Brain topography · 2023Article
- Electromagnetic source imaging predicts surgical outcome in children with focal cortical dysplasia.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Article
- Spike propagation mapping reveals effective connectivity and predicts surgical outcome in epilepsy.Brain : a journal of neurology · 2023Article
- Functional connectivity discriminates epileptogenic states and predicts surgical outcome in children with drug resistant epilepsy.Scientific reports · 2023Article
- Non-invasive mapping of epileptogenic networks predicts surgical outcome.Brain : a journal of neurology · 2023Article
- Ideal current dipoles are appropriate source representations for simulating neurons for intracranial recordings.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Article
- Virtual implantation using conventional scalp EEG delineates seizure onset and predicts surgical outcome in children with epilepsy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022Article
- Case Report: Laser Ablation Guided by State of the Art Source Imaging Ends an Adolescent's 16-Year Quest for Seizure Freedom.Frontiers in human neuroscience · 2022Article
- SEEG in 3D: Interictal Source Localization From Intracerebral Recordings.Frontiers in neurology · 2022Article
- Electric Source Imaging on Intracranial EEG Localizes Spatiotemporal Propagation of Interictal Spikes in Children with Epilepsy.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2021Article
- Mapping Functional Connectivity of Epileptogenic Networks through Virtual Implantation.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2021Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 3 countries.
Funding
Abstract
objectiveTo localize the seizure onset zone (SOZ) and irritative zone (IZ) using electric source imaging (ESI) on intracranial EEG (iEEG) and assess their clinical value in predicting epilepsy surgery outcome in children with focal cortical dysplasia (FCD).
methodsWe analyzed iEEG data from 25 children with FCD-associated medically refractory epilepsy (MRE) who underwent surgery. We performed ESI on ictal onset to localize SOZ (ESI-SOZ) and on interictal discharges to localize IZ (ESI-IZ). We tested whether resection of ESI-SOZ and ESI-IZ predicted good surgical outcome (Engel 1). We further compared the prediction performance of ESI-SOZ and ESI-IZ to those of SOZ and IZ defined using conventional methods, i.e. by identifying iEEG-contacts showing ictal onsets (conventional-SOZ) or being the most interictally active (conventional-IZ).
resultsThe proximity of ESI-SOZ (p = 0.043, odds-ratio = 3.9) and ESI-IZ (p = 0.011, odds-ratio = 7.04) to resection has higher effect on patients' outcome than proximity of conventional-SOZ (p = 0.17, odds-ratio = 1.7) and conventional-IZ (p = 0.038, odds-ratio = 2.6). Resection of ESI-SOZ and ESI-IZ presented higher discriminative power in predicting outcome (68% and 60%) than conventional-SOZ and conventional-IZ (48% and 53%).
conclusionsLocalizing SOZ and IZ via ESI on iEEG offers higher predictive value compared to conventional-iEEG interpretation. SIGNIFICANCE: iEEG-ESI may help surgical planning and facilitate prognostic assessment of children with FCD-associated MRE.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.