Observational studyEarly human development2020
Sociodemographic and medical influences on neurobehavioral patterns in preterm infants: A multi-center study.
Observational study in Early human development, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Immersive physical and occupational therapy in the neonatal intensive care unit: a non-randomized comparative cohort trial protocol.Pilot and feasibility studies · 2026Article
- Trajectories of attention problems in preschoolers born very preterm.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- Neurobehavioral outcomes of preterm infants: toward a holistic approach.Pediatric research · 2025Review
- The application of fecal microbiota transplantation in Parkinson's disease.Frontiers in aging neuroscience · 2025Review
- Association of Growth During Infancy with Neurodevelopment and Obesity in Children Born Very Preterm: The Environmental Influences on Child Health Outcomes Cohort.The Journal of pediatrics · 2024Article
- Risk Factors for Postpartum Depression and Severe Distress among Mothers of Very Preterm Infants at NICU Discharge.American journal of perinatology · 2024Article
- Neonatal neurobehavior associated with developmental changes from age 2 to 3 in very preterm infants.Early human development · 2024Article
- Preeclampsia, Fetal Growth Restriction, and 24-Month Neurodevelopment in Very Preterm Infants.JAMA network open · 2024Article
- Epigenetic age acceleration, neonatal morbidities, and neurobehavioral profiles in infants born very preterm.Epigenetics · 2023Article
- Maternal Prenatal Risk Phenotypes and Neurobehavioral Outcomes among Infants Born Very Preterm.The Journal of pediatrics · 2023Article
- Neurobehavioral and Medical Correlates of Autism Screening: 2-Year Outcomes for Infants Born Very Preterm.The Journal of pediatrics · 2023Article
- Prenatal and perinatal factors associated with neonatal neurobehavioral profiles in the ECHO Program.Pediatric research · 2023Article
- Neighborhood Deprivation and Association With Neonatal Intensive Care Unit Mortality and Morbidity for Extremely Premature Infants.JAMA network open · 2023Article
- Environmental influences on child health outcomes: cohorts of individuals born very preterm.Pediatric research · 2023Review
- Acoustic Cry Characteristics in Preterm Infants and Developmental and Behavioral Outcomes at 2 Years of Age.JAMA network open · 2023Article
- Neurobehavior in very preterm infants with low medical risk and full-term infants.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Neonatal Intensive Care Unit Network Neurobehavioral Scale Profiles in Full-Term Infants: Associations with Maternal Adversity, Medical Risk, and Neonatal Outcomes.The Journal of pediatrics · 2022Observational
- Analysis of Neonatal Neurobehavior and Developmental Outcomes Among Preterm Infants.JAMA network open · 2022Article
- Association of Abnormal Findings on Neonatal Cranial Ultrasound With Neurobehavior at Neonatal Intensive Care Unit Discharge in Infants Born Before 30 Weeks' Gestation.JAMA network open · 2022Article
- Associations between maternal pre-pregnancy body mass index and neonatal neurobehavior in infants born before 30 weeks gestation.Journal of perinatology : official journal of the California Perinatal Association · 2022Observational
Corrections and comments
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Authors and funding
12 authors at 9 institutions in 1 country.
Funding
Abstract
backgroundAmong preterm infants, neurodevelopmental outcomes are influenced by both medical and sociodemographic factors. Less is known about the impact on these factors on neonatal neurobehavioral patterns.
objectiveTo determine associations between demographic, psychosocial and medical risk factors and neonatal neurobehavior.
methodsMulti-center observational study of infants born <30 weeks enrolled in the Neonatal Neurobehavior and Outcomes in Very Preterm Infants (NOVI) Study between April 2014-May 2016. Maternal medical, demographic, and psychological variables and infant medical variables were prospectively collected. Demographic, substance, psychological and medical risk indices were developed. Neurobehavioral assessment was performed using the NICU Network Neurobehavioral Scale (NNNS) at NICU discharge.
results709 infants were enrolled in the NOVI study, and for 679 infants with neurobehavioral assessments, 6 NNNS behavioral profiles were calculated using latent profile analysis. Profile 6 infants (n = 47/679, 7%) were atypical, having poor attention, self-regulation and movement quality, hypertonia and increased stress signs. After adjustment for site, profile 6 infants had significantly smaller head circumferences at birth (β -0.87; -1.59, -0.14), and higher rates of late sepsis (OR 3.38; CI 1.66, 6.92) compared to Profiles 1-5 infants. There were no significant differences in other neonatal morbidities between the two groups. Profile 6 infants had a higher prenatal demographic risk score (1.46 vs 1.07;β 0.34; CI 0.06, 0.61) compared to Profiles 1-5 infants.
conclusionNNNS behavioral profiles identify an atypical behavioral pattern that is associated with early influences of demographic and medical variables. Such behavioral patterns may be seen as early as NICU discharge.
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