ArticleThe Journal of thoracic and cardiovascular surgery2021
Stage 1 acute kidney injury is independently associated with infection following cardiac surgery.
Article in The Journal of thoracic and cardiovascular surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 62 citations in OpenAlex.
- Intraoperative Dexmedetomidine Enhances Postoperative Microcirculation and Reduces Acute Kidney Injury in Cardiac Surgery: A Double-Blind Randomized Trial.Drug design, development and therapy · 2025Trial
- AKI as a systemic syndrome and its impact on other organ systems.Critical care (London, England) · 2026Review
- Comparison of the efficacy of the oXiris filter and the ST-100 filter in patients with postoperative cardiac surgery infections combined with acute kidney injury: a retrospective cohort study.Journal of cardiothoracic surgery · 2026Article
- Case Report: A case of acute kidney injury due to star fruit-infused liquor.Frontiers in medicine · 2026Article
- Effect of intraoperative hypotension depth and duration on acute kidney injury after Type A acute aortic dissection repair: An observational cohort study based on early risk stratification models.Journal of anesthesia and translational medicine · 2025Article
- Acute skeletal muscle wasting in patients with acute kidney injury requiring continuous kidney replacement therapy: A prospective multicenter study.Journal of critical care · 2025Observational
- Clustering analysis of multi-site electronic health records reveals distinct subphenotypes in stage-1 acute kidney injury.Communications medicine · 2025Article
- Postoperative acute kidney injury is associated with persistent renal dysfunction: a multicentre propensity-matched cohort study.BJA open · 2025Article
- Comparative Effectiveness of On-Pump Versus Off-Pump Coronary Surgical Revascularization Related to Postoperative Acute Kidney Injury.The American journal of cardiology · 2025Article
- Persistent Lymphopenia as a Poor Prognostic Factor in Patients With Multiple Organ Dysfunction Syndrome in the Renal Intensive Care Unit: A Retrospective Single-Center Study.Immunity, inflammation and disease · 2025Observational
- Immune profiling of critically ill patients with acute kidney injury during the first week after various types of injuries: the REALAKI study.Critical care (London, England) · 2024Article
- Preoperative endothelial dysfunction for the prediction of acute kidney injury after cardiac surgery using cardiopulmonary bypass: a pilot study based on a second analysis of the MONS study.Perioperative medicine (London, England) · 2024Article
- Improved early risk stratification of deep sternal wound infection risk after coronary artery bypass grafting.Journal of cardiothoracic surgery · 2024Article
- Perioperative Acute Kidney Injury: Implications, Approach, Prevention.Advances in anesthesia · 2023Review
- Article
- Risk Factors for Death Among Veterans Following Acute Kidney Injury.The American journal of medicine · 2023Article
- Fibrinogen is an independent preoperative predictor of hospital length of stay among patients undergoing coronary artery bypass grafting.Journal of cardiothoracic surgery · 2023Article
- The influence of continuous renal replacement therapy on 1,3-β-d-glucan levels in critically ill patients: a single-center retrospective propensity score study.Renal failure · 2023Article
- Association Between Nadir Hematocrit and Severe Acute Kidney Injury After Off-Pump Coronary Artery Bypass Graft Surgery: A Retrospective Cohort Study Based on the MIMIC-IV Database.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Risk Factors for Post-cardiac Surgery Infections.Cureus · 2022Article
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10 authors at 1 institution in 1 country.
Funding
Abstract
objectivesSevere acute kidney injury (AKI) is a known risk factor for infection and mortality. However, whether stage 1 AKI is a risk factor for infection has not been evaluated in adults. We hypothesized that stage 1 AKI following cardiac surgery would independently associate with infection and mortality.
methodsIn this retrospective propensity score-matched study, we evaluated 1620 adult patients who underwent nonemergent cardiac surgery at the University of Colorado Hospital from 2011 to 2017. Patients who developed stage 1 AKI by Kidney Disease Improving Global Outcomes creatinine criteria within 72 hours of surgery were matched to patients who did not develop AKI. The primary outcome was an infection, defined as a new surgical-site infection, positive blood or urine culture, or development of pneumonia. Secondary outcomes included in-hospital mortality, stroke, and intensive care unit (ICU) and hospital length of stay (LOS).
resultsStage 1 AKI occurred in 293 patients (18.3%). Infection occurred in 20.9% of patients with stage 1 AKI compared with 8.1% in the no-AKI group (P < .001). In propensity-score matched analysis, stage 1 AKI independently associated with increased infection (odds ratio [OR]; 2.24, 95% confidence interval [CI], 1.37-3.17), ICU LOS (OR, 2.38; 95% CI, 1.71-3.31), and hospital LOS (OR, 1.30; 95% CI, 1.17-1.45).
conclusionsStage 1 AKI is independently associated with postoperative infection, ICU LOS, and hospital LOS. Treatment strategies focused on prevention, early recognition, and optimal medical management of AKI may decrease significant postoperative morbidity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.