ArticleLancet (London, England)2020
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study.
67 registry-linked trialsAbstract read
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Article in Lancet (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 67 registered trials, which are not on this map. Cited by 10,459 papers, 5 of them syntheses that pooled it.
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Who cites it
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Authors and funding
14 authors.
Nanshan ChenTuberculosis and Respiratory Department, Wuhan Jinyintan Hospital, Wuhan, China.
Min ZhouDepartment of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Institute of Respiratory Diseases, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Xuan DongTuberculosis and Respiratory Department, Wuhan Jinyintan Hospital, Wuhan, China.
Jieming QuDepartment of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Institute of Respiratory Diseases, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Fengyun GongInfection Disease Department, Wuhan Jinyintan Hospital, Wuhan, China.
Yang HanScience and Education Department, Wuhan Jinyintan Hospital, Wuhan, China; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Yang QiuState Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Jingli WangInfection Disease Department, Wuhan Jinyintan Hospital, Wuhan, China.
Ying LiuThe Office of Drug Clinical Trial Institution, Wuhan Jinyintan Hospital, Wuhan, China.
Yuan WeiTuberculosis and Respiratory Department, Wuhan Jinyintan Hospital, Wuhan, China.
Jia'an XiaTuberculosis and Respiratory Department, Wuhan Jinyintan Hospital, Wuhan, China.
Ting YuTuberculosis and Respiratory Department, Wuhan Jinyintan Hospital, Wuhan, China.
Xinxin ZhangResearch Laboratory of Clinical Virology, Ruijin Hospital and Ruijin Hospital North, Shanghai Jiaotong University School of Medicine, Shanghai, China; Clinical Research Center, Ruijin Hospital North, Shanghai Jiaotong University School of Medicine, Shanghai, China. Electronic address: zhangx@shsmu.edu.cn.
Li ZhangTuberculosis and Respiratory Department, Wuhan Jinyintan Hospital, Wuhan, China. Electronic address: zhangli080806@163.com.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn December, 2019, a pneumonia associated with the 2019 novel coronavirus (2019-nCoV) emerged in Wuhan, China. We aimed to further clarify the epidemiological and clinical characteristics of 2019-nCoV pneumonia.
methodsIn this retrospective, single-centre study, we included all confirmed cases of 2019-nCoV in Wuhan Jinyintan Hospital from Jan 1 to Jan 20, 2020. Cases were confirmed by real-time RT-PCR and were analysed for epidemiological, demographic, clinical, and radiological features and laboratory data. Outcomes were followed up until Jan 25, 2020.
findingsOf the 99 patients with 2019-nCoV pneumonia, 49 (49%) had a history of exposure to the Huanan seafood market. The average age of the patients was 55·5 years (SD 13·1), including 67 men and 32 women. 2019-nCoV was detected in all patients by real-time RT-PCR. 50 (51%) patients had chronic diseases. Patients had clinical manifestations of fever (82 [83%] patients), cough (81 [82%] patients), shortness of breath (31 [31%] patients), muscle ache (11 [11%] patients), confusion (nine [9%] patients), headache (eight [8%] patients), sore throat (five [5%] patients), rhinorrhoea (four [4%] patients), chest pain (two [2%] patients), diarrhoea (two [2%] patients), and nausea and vomiting (one [1%] patient). According to imaging examination, 74 (75%) patients showed bilateral pneumonia, 14 (14%) patients showed multiple mottling and ground-glass opacity, and one (1%) patient had pneumothorax. 17 (17%) patients developed acute respiratory distress syndrome and, among them, 11 (11%) patients worsened in a short period of time and died of multiple organ failure.
interpretationThe 2019-nCoV infection was of clustering onset, is more likely to affect older males with comorbidities, and can result in severe and even fatal respiratory diseases such as acute respiratory distress syndrome. In general, characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia. Further investigation is needed to explore the applicability of the MuLBSTA score in predicting the risk of mortality in 2019-nCoV infection.
fundingNational Key R&D Program of China.
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AdultAgedAged, 80 and overChinaComorbidityCoronavirus InfectionsCoughCOVID-19Disease OutbreaksDyspneaFemaleFeverHumansMaleMiddle AgedPneumonia, Viral
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