Evidence map›Paper›PMID 32006606›Full record

ReviewExperimental hematology2020

Clones assemble! The clonal complexity of blood during ontogeny and disease.

Miguel Ganuza, Trent Hall, Esther A Obeng, Shannon McKinney-Freeman

Abstract readReview
In one paragraph

Review in Experimental hematology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. The evolving hematopoietic niche during development.Frontiers in molecular biosciences · 2024
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Hematopoiesis during Ontogenesis, Adult Life, and Aging.International journal of molecular sciences · 2021
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Miguel GanuzaDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, TN.
Trent HallDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, TN.
Esther A ObengDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN.
Shannon McKinney-FreemanDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, TN. Electronic address: Shannon.McKinney-Freeman@stjude.org.

Funding

Defining Nfix's role as a novel key regulator of hematopoietic stem cellsR01DK104028 · NIDDK · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI MCKINNEY-FREEMAN, SHANNON L · 2016 to 2020
$2.0M
Improving HSC transplantation by defining novel regulators of engraftmentR01DK116835 · NIDDK · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI MCKINNEY-FREEMAN, SHANNON L · 2019 to 2022
$1.6M
Characterizing a novel developmental checkpoint during hematopoietic stem cell ontogenyF31DK118798 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI HALL, TRENT · 2018 to 2019
$90k
NIDDK NIH HHS F31 DK118798NIDDK NIH HHS R01 DK104028NIDDK NIH HHS R01 DK116835
6 · The paper itself

Abstract

Hematopoietic stem and progenitor cells (HSPCs) govern the daily expansion and turnover of billions of specialized blood cells. Given their clinical utility, much effort has been made toward understanding the dynamics of hematopoietic production from this pool of stem cells. An understanding of hematopoietic stem cell clonal dynamics during blood ontogeny could yield important insights into hematopoietic regulation, especially during aging and repeated exposure to hematopoietic stress-insults that may predispose individuals to the development of hematopoietic disease. Here, we review the current state of research regarding the clonal complexity of the hematopoietic system during embryogenesis, adulthood, and hematologic disease.

Indexed as

HematopoiesisStress, PhysiologicalAdultHematologic DiseasesHematopoietic Stem CellsHumans

Identifiers

PMID32006606
PMCPMC8343955

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.