ArticleMedical science monitor : international medical journal of experimental and clinical research2020
Changes in Serum Amyloid A (SAA) and 8-OHdG in Patients with Senile Early Cognitive Impairment.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Oxidative stress biomarkers and flavonoids in Alzheimer's disease: current clinical evidence and therapeutic perspectives.Redox report : communications in free radical research · 2026Review
- Mechanisms and biomarkers of poststroke cognitive impairment.Neural regeneration research · 2026Article
- Alpha-lipoic acid alleviates oxidative stress and brain damage in patients with sevoflurane anesthesia.Frontiers in pharmacology · 2025Article
- Correlation of telomere length and DNA damage markers with severity and associated depressive states in patients with OSAS.Frontiers in neurology · 2025Article
- Added value of inflammatory plasma biomarkers to pathologic biomarkers in predicting preclinical Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2024Article
- Association of 8-hydroxy-2'-deoxyguanosine with motoric cognitive risk in elderly Chinese people: RUGAO longevity and aging cross-sectional study.BMC geriatrics · 2024Article
- PKR downregulation prevents copper-induced synaptic dysfunction and cognitive impairment in a murine model of Wilson's disease.Frontiers in neuroscience · 2024Article
- 27-hydroxycholesterol causes cognitive deficits by disturbing Th17/Treg balance and the related immune responses in mild cognitive impairment patients and C57BL/6J mice.Journal of neuroinflammation · 2023Article
- Jia-Wei-Kai-Xin-San Treatment Alleviated Mild Cognitive Impairment through Anti-Inflammatory and Antiapoptotic Mechanisms in SAMP8 Mice.Mediators of inflammation · 2023Article
- Oxidized carbon black nanoparticles induce endothelial damage through C-X-C chemokine receptor 3-mediated pathway.Redox biology · 2021Article
- Connection between the Altered HDL Antioxidant and Anti-Inflammatory Properties and the Risk to Develop Alzheimer's Disease: A Narrative Review.Oxidative medicine and cellular longevity · 2021Review
- Elevated Serum Amyloid A Is Associated With Cognitive Impairment in Ischemic Stroke Patients.Frontiers in neurology · 2021Article
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Authors and funding
2 authors.
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Abstract
BACKGROUND This study assessed variations in SAA and 8-OHdG in patients with senile early cognitive impairment (CI). MATERIAL AND METHODS The subjects were divided into 3 groups: 121 patients with mild cognitive impairment (MCI), 131 with Alzheimer's disease (AD), and 100 healthy persons that underwent physical examinations during the same period (Control). These groups were evaluated by MMSE and MoCA, and the SAA and 8-OHdG levels in these groups were tested using ELISA sandwich technique. RESULTS The AD group had significantly higher TG and ApoB levels, followed by the MCI and Control groups, respectively (P<0.05). The MCI group had the highest HDL-C level significantly, while the Control group had the lowest (P<0.05). The Control (normal) group had significantly higher MoCA and MMSE scores, followed by the MCI group and the AD group (P<0.05). The Control (normal) group had significantly lower SAA and 8-OHdG levels, followed by the MCI group and the AD group (P<0.05). The MoCA and MMSE scores and serum 8-OHdG and serum SAA levels in the 3 groups were negatively correlated, but their SAA and 8-OHdG levels were positively correlated. CONCLUSIONS SAA and 8-OHdG in the MCI and AD groups were highly expressed but had an inverse correlation with cognitive function scores (hereafter referred to as CFs scores). They can also be applied as test indicators of MCI. We also detected an apparent link between SAA and 8-OHdG.
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