ArticleAging clinical and experimental research2020
Operationalization of a frailty index among older adults in the InCHIANTI study: predictive ability for all-cause and cardiovascular disease mortality.
Article in Aging clinical and experimental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Frailty and risks of all-cause and cause-specific death in community-dwelling adults: a systematic review and meta-analysis.BMC geriatrics · 2022Pooled it
- Frailty among older adults in Germany: regional variation across NAKO study centers.International journal for equity in health · 2026Article
- Article
- Neural embedding of frailty in cognitively unimpaired aging and dementia across Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Association Between Ultra-Processed Food Consumption Frequency and Frailty: Findings from the InCHIANTI Study of Aging.Geriatrics (Basel, Switzerland) · 2025Article
- Predicting cardiovascular morbidity and mortality with SCORE2 (OP) and Framingham risk estimates in combination with indicators of biological ageing.Age and ageing · 2025Article
- Measuring Frailty Using Self-Report or Automated Tools to Identify Risk of Cardiovascular Events and Mortality: The Million Veteran Program.Journal of the American Heart Association · 2024Article
- Frailty predicts all-cause and cause-specific mortality among older adults in Austria: 8-year mortality follow-up of the Austrian Health Interview Survey (ATHIS 2014).BMC geriatrics · 2024Article
- Frailty and Cardiovascular Mortality: A Narrative Review.Current cardiology reports · 2023Review
- Resting metabolic rate in relation to incident disability and mobility decline among older adults: the modifying role of frailty.Aging clinical and experimental research · 2023Article
- Article
- Impact of preoperative laboratory frailty index on mortality and clinical outcomes in older surgical patients with cancer.Scientific reports · 2022Article
- Trajectories of Frailty With Aging: Coordinated Analysis of Five Longitudinal Studies.Innovation in aging · 2022Article
- Early-Life Socioeconomic Position and the Accumulation of Health-Related Deficits by Midlife in the 1958 British Birth Cohort Study.American journal of epidemiology · 2021Article
- Trends in Frailty and Its Association With Mortality: Results From the Longitudinal Aging Study Amsterdam, 1995-2016.American journal of epidemiology · 2021Article
- Association of Adherence to the Mediterranean-Style Diet with Lower Frailty Index in Older Adults.Nutrients · 2021Article
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6 authors.
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Abstract
backgroundThe frailty index (FI) is a sensitive instrument to measure the degree of frailty in older adults, and is increasingly used in cohort studies on aging.
aimsTo operationalize an FI among older adults in the "Invecchiare in Chianti" (InCHIANTI) study, and to validate its predictive capacity for mortality.
methodsLongitudinal data were used from 1129 InCHIANTI participants aged ≥ 65 years. A 42-item FI was operationalized following a standard procedure using baseline data (1998/2000). Associations of the FI with 3- and 6-year all-cause and cardiovascular disease (CVD) mortality were studied using Cox regression. Predictive accuracy was estimated by the area under the ROC curve (AUC), for a continuous FI score and for different cut-points.
resultsThe median FI was 0.13 (IQR 0.08-0.21). Scores were higher in women, and at advanced age. The FI was associated with 3- and 6-year all-cause and CVD mortality (HR range per 0.01 FI increase = 1.03-1.07, all p < 0.001). The continuous FI score predicted the mortality outcomes with moderate-to-good accuracy (AUC range 0.72-0.83). When applying FI cut-offs between 0.15 and 0.35, the accuracy of this FI for predicting mortality was moderate (AUC range 0.61-0.76). Overall, the predictive accuracy of the FI was higher in women than in men.
conclusionsThe FI operationalized in the InCHIANTI study is a good instrument to grade the risk of all-cause mortality and CVD mortality. More measurement properties, such as the responsiveness of this FI when used as outcome measure, should be investigated in future research.
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