Evidence map›Paper›PMID 32006333›Full record

ArticleEnvironmental science and pollution research international2020

Cell membrane damage induced by continuous stress of artemisinin sustained-release microspheres (ASMs) on Microcystis aeruginosa at different physiological stages.

Lixiao Ni, Feifei Yue, Jianhua Zhang, Shiyi Rong, Xuanyu Liu, Yifei Wang, Peifang Wang, Danye Li, Na Wang, Hanqi Wu and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Environmental science and pollution research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 17 citations in OpenAlex.

  1. Isolation of a NovelToxins · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Lixiao NiKey Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, MOE; School of Environment, Hohai University, Nanjing, 210098, China.
Feifei YueKey Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, MOE; School of Environment, Hohai University, Nanjing, 210098, China.
Jianhua ZhangJiangsu Provincial Water Conservancy Department, Nanjing, 210029, China.
Shiyi RongKey Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, MOE; School of Environment, Hohai University, Nanjing, 210098, China.
Xuanyu LiuKey Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, MOE; School of Environment, Hohai University, Nanjing, 210098, China.
Yifei WangKey Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, MOE; School of Environment, Hohai University, Nanjing, 210098, China.
Peifang WangKey Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, MOE; School of Environment, Hohai University, Nanjing, 210098, China.
Danye LiSchool of Environment, Nanjing Normal University, Nanjing, 210097, China.
Na WangKey Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, MOE; School of Environment, Hohai University, Nanjing, 210098, China.
Hanqi WuKey Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, MOE; School of Environment, Hohai University, Nanjing, 210098, China.
Shiyin LiSchool of Environment, Nanjing Normal University, Nanjing, 210097, China. lishiyin@njnu.edu.cn.
Hohai University · CNNanjing Normal University · CNJiangsu Provincial Water Survey & Design Institute (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Artemisinin sustained-release microspheres (ASMs) with long-term inhibition effects (> 40 days) on harmful freshwater bloom-forming cyanobacteria have been found in previous studies, but the inhibition mechanism is not completely clear. In the present study, we examined the growth effect of ASMs on Microcystis aeruginosa (M. aeruginosa) cells at different physiological stages. Growth experiments indicated that M. aeruginosa of different initial densities could be inhibited immediately and chlorophyll-a content both showed significant decreases following exposure of cyanobacteria to optimal dosage of ASMs for 20 days. The algicidal mechanism of ASMs was tested through a suite of physiological parameters (membrane permeability, antioxidant enzymes activity, and lipid peroxidation). The rise of cell membrane permeability indices (intracellular protein, nucleic acid contents, and conductivity) showed that the cellular membrane structure of M. aeruginosa was attacked by ASMs directly causing the leakage of cytoplasm. Antioxidant enzyme activity was a sensitive indicator of the impacts of ASMs which showed a significant downtrend after a few days. ASMs caused a great increase in •O

Indexed as

ArtemisininsMicrocystisCell MembraneDelayed-Action PreparationsMicrospheresArtemisininsDelayed-Action PreparationsAntioxidant enzymeArtemisinin sustained-release microspheresCell membrane damageChlorophyll-aMechanismMicrocystis aeruginosa

Identifiers

PMID32006333
OpenAlexW3004223948

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.