Evidence map›Paper›PMID 32006272›Full record

ArticleJournal of autism and developmental disorders2020

Autism Spectrum Disorder Symptoms are Associated with Connectivity Between Large-Scale Neural Networks and Brain Regions Involved in Social Processing.

Korey P Wylie, Jason R Tregellas, Joshua J Bear, Kristina T Legget

Abstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Korey P WylieDepartment of Psychiatry, University of Colorado School of Medicine, Anschutz Medical Campus, Fitzsimons Building, Mail Stop F546, 13001 East 17th Place, Aurora, CO, 80045, USA.
Jason R TregellasDepartment of Psychiatry, University of Colorado School of Medicine, Anschutz Medical Campus, Fitzsimons Building, Mail Stop F546, 13001 East 17th Place, Aurora, CO, 80045, USA.
Joshua J BearDepartment of Pediatrics, Section of Neurology, Children's Hospital Colorado, 13123 East 16th Avenue, Aurora, CO, 80045, USA.
Kristina T LeggetDepartment of Psychiatry, University of Colorado School of Medicine, Anschutz Medical Campus, Fitzsimons Building, Mail Stop F546, 13001 East 17th Place, Aurora, CO, 80045, USA. Kristina.Legget@ucdenver.edu.ORCID http://orcid.org/0000-0002-2948-506X

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Development of Psychopathology, Psychobiology, & BehaviorT32MH015442 · NIMH · UNIVERSITY OF COLORADO DENVER · PI JASON R TREGELLAS · 1985 to 2026
$10.2M
Neuronal Effects of Exercise on SchizophreniaR01MH102224 · NIMH · UNIVERSITY OF COLORADO DENVER · PI TREGELLAS, JASON R · 2014 to 2018
$1.9M
Nicotinic Agonist Effects on BMI and Neuronal Response in Overweight/Obese AdultsR01DK103691 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI TREGELLAS, JASON R · 2015 to 2019
$1.9M
Effects of Exercise on Neuronal Activity in Obese IndividualsK01DK100445 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LEGGET, KRISTINA T · 2014 to 2018
$691k
Neuronal and Behavioral Effects of Implicit Priming in Obese IndividualsR21DK102052 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI TREGELLAS, JASON R · 2014 to 2015
$427k
Reducing Hippocampal Hyperactivity and Improving Cognition in SchizophreniaI01CX001414 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI TREGELLAS, JASON R · 2018 to 2023
–
CSRD Research Career Scientist Award ApplicationIK6CX002178 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI JASON R TREGELLAS · 2020 to 2026
–
CSRD VA I01 CX001414CSRD VA IK6 CX002178NCATS NIH HHS UL1 TR002535NCATS NIH HHS UL1TR002535NIDDK NIH HHS K01 DK100445NIDDK NIH HHS K01DK100445NIDDK NIH HHS R01 DK103691NIDDK NIH HHS R01DK103691NIDDK NIH HHS R21 DK102052NIDDK NIH HHS R21DK102052NIMH NIH HHS R01 MH102224NIMH NIH HHS R01MH102224NIMH NIH HHS T32 MH015442
6 · The paper itself

Abstract

The neurobiology of autism spectrum disorder remains poorly understood. The present study addresses this knowledge gap by examining the relationship between functional brain connectivity and Autism Diagnostic Observation Schedule (ADOS) scores using publicly available data from the Autism Brain Imaging Data Exchange (ABIDE) database (N = 107). This relationship was tested across all brain voxels, without a priori assumptions, using a novel statistical approach. ADOS scores were primarily associated with decreased connectivity to right temporoparietal junction, right anterior insula, and left fusiform gyrus (p < 0.05, corrected). Seven large-scale brain networks influenced these associations. Findings largely encompassed brain regions involved in processing socially relevant information, highlighting the importance of these processes in autism spectrum disorder.

Indexed as

AdolescentAutism Spectrum DisorderBrainBrain MappingCerebral CortexFemaleHumansMagnetic Resonance ImagingMaleNeural PathwaysNeuroimagingTemporal LobeABIDEADOSDistance covarianceFunctional connectivityIndependent components analysis

Identifiers

PMID32006272
PMCPMC7377948

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.