ArticleAnnals of biomedical engineering2020
Personalized Dosimetry for Liver Cancer Y-90 Radioembolization Using Computational Fluid Dynamics and Monte Carlo Simulation.
Article in Annals of biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- AAPM Medical Physics Practice Guideline 14.a: Yttrium-90 microsphere radioembolization.Journal of applied clinical medical physics · 2024Guideline
- Transarterial radioembolization: a systematic review on gaining control over the parameters that influence microsphere distribution.Drug delivery · 2023Pooled it
- Therapeutic embolic agents for targeted drug delivery in transcatheter therapies: a review.Chemical communications (Cambridge, England) · 2026Review
- Computational Fluid Dynamics Simulations to Inform Cancer Therapeutics.Annual review of biomedical engineering · 2026Review
- The impact of microsphere deposition algorithm complexity on microdosimetry following Yttrium-90 radioembolization.Biomedical physics & engineering express · 2026Article
- Toward Digital Twins for Optimal Radioembolization.PET clinics · 2026Review
- Radioembolization for Hepatocellular Carcinoma: a Comparison on Dual-phase Cone-beam CT, Contrast-enhanced CT (CECT) andLa Radiologia medica · 2025Observational
- The evolution and significance of embolization efficiency index (EEI) during transcatheter hepatic arterial embolization procedure: a pilot study based on computational fluid dynamics.Frontiers in bioengineering and biotechnology · 2025Article
- Article
- Development of a High-Fidelity Benchtop Model for Simultaneous Flow, Pressure, and Imaging Assessment of Transarterial Embolization Procedures.Cardiovascular engineering and technology · 2024Article
- Translating contrast enhanced computed tomography images to liver radioembolization dose distribution for more comprehensively indicating patients.Physics in medicine and biology · 2024Article
- A Review of Image-Based Simulation Applications in High-Value Manufacturing.Archives of computational methods in engineering : state of the art reviews · 2023Review
- Article
- Prediction of Lung Shunt Fraction for Yttrium-90 Treatment of Hepatic Tumors Using Dynamic Contrast Enhanced MRI with Quantitative Perfusion Processing.Tomography (Ann Arbor, Mich.) · 2022Article
- The OpenGATE ecosystem for Monte Carlo simulation in medical physics.Physics in medicine and biology · 2022Review
- Towards personalised dosimetry in patients with liver malignancy treated withEJNMMI physics · 2022Article
- Radioembolization Dosimetry with Total-BodyJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022Article
- The Impact of Injection Distance to Bifurcations on Yttrium-90 Distribution in Liver Cancer Radioembolization.Journal of vascular and interventional radiology : JVIR · 2022Article
- Computational Fluid Dynamics Modeling of Liver Radioembolization: A Review.Cardiovascular and interventional radiology · 2022Review
- A Hybrid Particle-Flow CFD Modeling Approach in Truncated Hepatic Arterial Trees for Liver Radioembolization: A Patient-specific Case Study.Frontiers in bioengineering and biotechnology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Yttrium-90 (Y-90) transarterial radioembolization uses radioactive microspheres injected into the hepatic artery to irradiate liver tumors internally. One of the major challenges is the lack of reliable dosimetry methods for dose prediction and dose verification. We present a patient-specific dosimetry approach for personalized treatment planning based on computational fluid dynamics (CFD) simulations of the microsphere transport combined with Y-90 physics modeling called CFDose. The ultimate goal is the development of a software to optimize the amount of activity and injection point for optimal tumor targeting. We present the proof-of-concept of a CFD dosimetry tool based on a patient's angiogram performed in standard-of-care planning. The hepatic arterial tree of the patient was segmented from the cone-beam CT (CBCT) to predict the microsphere transport using multiscale CFD modeling. To calculate the dose distribution, the predicted microsphere distribution was convolved with a Y-90 dose point kernel. Vessels as small as 0.45 mm were segmented, the microsphere distribution between the liver segments using flow analysis was predicted, the volumetric microsphere and resulting dose distribution in the liver volume were computed. The patient was imaged with positron emission tomography (PET) 2 h after radioembolization to evaluate the Y-90 distribution. The dose distribution was found to be consistent with the Y-90 PET images. These results demonstrate the feasibility of developing a complete framework for personalized Y-90 microsphere simulation and dosimetry using patient-specific input parameters.
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Registered trials
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