ArticleAnnals of biomedical engineering2020
Mechanics of Porcine Heart Valves' Strut Chordae Tendineae Investigated as a Leaflet-Chordae-Papillary Muscle Entity.
Article in Annals of biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Effect of Parametric Variation of Chordae Tendineae Structure on Simulated Atrioventricular Valve Closure.Annals of biomedical engineering · 2026Article
- State-space formulations to understand the nonlinear viscoelastic mechanical behavior of tricuspid valve chordae tendineae.Applied mathematical modelling · 2026Article
- Reverse impact of chordae tendineae structural changes on its biomechanical properties as a part of pathogenesis in canine myxomatous mitral valve disease.BMC veterinary research · 2025Article
- FEBio FINESSE: An Open-Source Finite Element Simulation Approach to Estimate In Vivo Heart Valve Strains Using Shape Enforcement.Annals of biomedical engineering · 2025Article
- Viscoelastic modelling of the tricuspid valve chordae tendineae tissue.Applied mathematical modelling · 2022Article
- Parameterization, geometric modeling, and isogeometric analysis of tricuspid valves.Computer methods in applied mechanics and engineering · 2021Article
- A pilot in silico modeling-based study of the pathological effects on the biomechanical function of tricuspid valves.International journal for numerical methods in biomedical engineering · 2020Article
- A Pilot Study on Linking Tissue Mechanics with Load-Dependent Collagen Microstructures in Porcine Tricuspid Valve Leaflets.Bioengineering (Basel, Switzerland) · 2020Article
- Mechanics and Microstructure of the Atrioventricular Heart Valve Chordae Tendineae: A Review.Bioengineering (Basel, Switzerland) · 2020Review
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
Abstract
Proper blood flow through the atrioventricular heart valves (AHVs) relies on the holistic function of the valve and subvalvular structures, and a failure of any component can lead to life-threatening heart disease. A comprehension of the mechanical characteristics of healthy valvular components is necessary for the refinement of heart valve computational models. In previous studies, the chordae tendineae have been mechanically characterized as individual structures, usually in a clamping-based approach, which may not accurately reflect the in vivo chordal interactions with the leaflet insertion and papillary muscles. In this study, we performed uniaxial mechanical testing of strut chordae tendineae of the AHVs under a unique tine-based leaflet-chordae-papillary muscle testing to observe the chordae mechanics while preserving the subvalvular component interactions. Results of this study provided insight to the disparity of chordae tissue stress-stretch responses between the mitral valve (MV) and the tricuspid valve (TV) under their respective emulated physiological loading. Specifically, strut chordae tendineae of the MV anterior leaflet had peak stretches of 1.09-1.16, while peak stretches of 1.08-1.11 were found for the TV anterior leaflet strut chordae. Constitutive parameters were also derived for the chordae tissue specimens using an Ogden model, which is useful for AHV computational model refinement. Results of this study are beneficial to the eventual improvement of treatment methods for valvular disease.
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