Evidence map›Paper›PMID 32006210›Full record

ArticleDigestive diseases and sciences2020

A Novel Method for the Prevention and Treatment of Small-for-Size Syndrome in Liver Transplantation.

Yanhu Feng, Zhijian Han, Baohong Gu, Xuemei Li, Bofang Wang, Facai Guo, Raaj Kumar Praseedom, Furong Wang, Huijuan Cheng, Alexandra Lucas and 2 more

RetractedAbstract readRetracted Publication
PubMed Publisher
In one paragraph

Article in Digestive diseases and sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Yanhu Feng *Department of Gastroenterology, Second Hospital of Lanzhou University, Lanzhou, 730030, China.
Zhijian Han *The Key Laboratory of the Digestive System Tumors of Gansu Province, Second Hospital of Lanzhou University, Lanzhou, 730030, China.
Baohong Gu *The Key Laboratory of the Digestive System Tumors of Gansu Province, Second Hospital of Lanzhou University, Lanzhou, 730030, China.
Xuemei Li *The Key Laboratory of the Digestive System Tumors of Gansu Province, Second Hospital of Lanzhou University, Lanzhou, 730030, China.
Bofang Wang *The Key Laboratory of the Digestive System Tumors of Gansu Province, Second Hospital of Lanzhou University, Lanzhou, 730030, China.
Facai GuoDepartment of Vascular Surgery, Second Hospital of Lanzhou University, Lanzhou, 730030, China.
Raaj Kumar PraseedomDepartment of Surgery, Addenbrooke's Hospital, Cambridge, UK.
Furong WangThe Key Laboratory of the Digestive System Tumors of Gansu Province, Second Hospital of Lanzhou University, Lanzhou, 730030, China.
Huijuan ChengThe Key Laboratory of the Digestive System Tumors of Gansu Province, Second Hospital of Lanzhou University, Lanzhou, 730030, China.
Alexandra LucasDepartment of Medicine, University of Florida, Gainesville, FL, USA.
Yumin LiDepartment of General Surgery, Second Hospital of Lanzhou University, Lanzhou, 730030, China.
Hao ChenDepartment of General Surgery, Second Hospital of Lanzhou University, Lanzhou, 730030, China. chenhao3996913@163.com.
Lanzhou University Second Hospital · CNAddenbrooke's Hospital · GBUniversity of Florida · US

Funding

Key Programme 31270532Key Programme 81670594
6 · The paper itself

Abstract

backgroundCurrently there is no consensus on the optimal management of small-for-size syndrome following liver transplantation. Here we describe a technique to alleviate portal hypertension and improve the hepatocyte reperfusion in small-for-size liver transplantation in a Lewis rat model.

methodsThe rats underwent trans-portal vein intra-hepatic portosystemic shunt using a self-developed porous conical tube (TPIPSS: Fig. 1) on small-for-size liver transplants (SFS) with right lobe graft. The treatment effect was evaluated by comparing hemodynamic parameters, morphological changes, serum parameters, ET-1 and eNOS expression, hepatocyte proliferation and apoptosis, CYP3A2 levels, postoperative complications, and survival between the two groups with SFS liver transplants.

resultsPorous conical prosthesis prolonged the filling time of small-for-size grafts. Moreover, grafts with TPIPSS showed a lower portal vein pressure, improved microcirculatory flow, alleviated histological changes, decreased ET-1 and increased eNOS expressions, and significantly less damage to liver function comparing to grafts without TPIPSS. Mean survival and overall 30-day survival were significantly higher in the TPIPSS group.

conclusionsThese results demonstrate that porous conical tube as trans-portal vein intra-hepatic portosystemic shunt device is an effective way to alleviate portal vein hypertension and improve hepatocyte reperfusion after small-for-size liver transplantation.

Indexed as

Blood Vessel ProsthesisAnimalsApoptosisBlood Vessel Prosthesis ImplantationCell ProliferationCytochrome P-450 CYP3AEndothelin-1HemodynamicsLiver CirculationLiver TransplantationMaleNitric Oxide Synthase Type IIIOrgan SizePorosityPortal VeinPostoperative ComplicationsCyp3a2 protein, ratCytochrome P-450 CYP3AEndothelin-1Nitric Oxide Synthase Type IIINos3 protein, ratLiver transplantationPorous conical tubePortal vein hypertensionSmall-for-size syndrome

Identifiers

PMID32006210
OpenAlexW3003544890

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.