Evidence map›Paper›PMID 32006158›Full record

ArticleJournal of neurology2020

The clinical profile of NMOSD in Australia and New Zealand.

Wajih Bukhari, Laura Clarke, Cullen O'Gorman, Elham Khalilidehkordi, Simon Arnett, Kerri M Prain, Mark Woodhall, Roger Silvestrini, Christine S Bundell, Sudarshini Ramanathan and 56 more

Abstract read
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In one paragraph

Article in Journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Observational
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

66 authors at 20 institutions in 4 countries.

Wajih Bukhari *Menzies Health Institute Queensland, School of Medicine, Griffith University, Gold Coast Campus, Gold Coast, QLD, 4222, Australia.
Laura Clarke *Menzies Health Institute Queensland, School of Medicine, Griffith University, Gold Coast Campus, Gold Coast, QLD, 4222, Australia.
Cullen O'GormanMenzies Health Institute Queensland, School of Medicine, Griffith University, Gold Coast Campus, Gold Coast, QLD, 4222, Australia.
Elham KhalilidehkordiMenzies Health Institute Queensland, School of Medicine, Griffith University, Gold Coast Campus, Gold Coast, QLD, 4222, Australia.
Simon ArnettMenzies Health Institute Queensland, School of Medicine, Griffith University, Gold Coast Campus, Gold Coast, QLD, 4222, Australia.
Kerri M PrainDepartment of Immunology, Pathology Queensland, Royal Brisbane and Women's Hospital, Herston, QLD, 4006, Australia.
Mark WoodhallNuffield Department of Clinical Neurosciences, John Radcliffe Infirmary, University of Oxford, Oxford, OX3 9DU, UK.
Roger SilvestriniDepartment of Immunopathology, Westmead Hospital, Westmead, NSW, 2145, Australia.
Christine S BundellSchool of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, WA, 6009, Australia.
Sudarshini RamanathanBrain Autoimmunity Group, Institute for Neuroscience and Muscle Research, The Kids Research Institute at the Children's Hospital, Westmead, NSW, 2145, Australia.
David AbernethyDepartment of Neurology, Wellington Hospital, Newtown, 6021, New Zealand.
Sandeep BhutaMenzies Health Institute Queensland, School of Medicine, Griffith University, Gold Coast Campus, Gold Coast, QLD, 4222, Australia.
Stefan BlumDepartment of Neurology, Princess Alexandra Hospital, Woolloongabba, QLD, 4102, Australia.
Mike BoggildDepartment of Neurology, Townsville Hospital, Douglas, QLD, 4814, Australia.
Karyn BoundyDepartment of Neurology, Royal Adelaide Hospital, Adelaide, SA, 5000, Australia.
Bruce J BrewCentre for Applied Medical Research, St Vincent's Hospital, University of New South Wales, Darlinghurst, NSW, 2010, Australia.
Wallace BrownleeDepartment of Neurology, Auckland City Hospital, Grafton, 1023, New Zealand.
Helmut ButzkuevenMelbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, 3010, Australia.
William M CarrollCentre for Neuromuscular and Neurological Disorders, Queen Elizabeth II Medical Centre, University of Western Australia, Nedlands, WA, 6009, Australia.
Celia ChenFlinders Medical Centre, Flinders University, Bedford Park, SA, 5042, Australia.
Alan CoulthardSchool of Medicine, Royal Brisbane and Women's Hospital, University of Queensland, Herston, QLD, 4029, Australia.
Russell C DaleThe Children's Hospital at Westmead, Faculty of Medicine and Health, University of Sydney, Westmead, NSW, 2145, Australia.
Chandi DasDepartment of Neurology, Canberra Hospital, Garran, ACT, 2605, Australia.
Keith DearGlobal Health Research Centre, Duke Kunshan University, Kunshan, Jiangsu, China.
Marzena J Fabis-PedriniWestern Australian Neuroscience Research Institute, Queen Elizabeth II Medical Centre, University of Western Australia, Nedlands, WA, 6009, Australia.
David FulcherSydney Medical School, Royal Prince Alfred Hospital, University of Sydney, Camperdown, NSW, 2006, Australia.
David GillisSchool of Medicine, Royal Brisbane and Women's Hospital, University of Queensland, Herston, QLD, 4029, Australia.
Simon HawkeSydney Medical School, Royal Prince Alfred Hospital, University of Sydney, Camperdown, NSW, 2006, Australia.
Robert HeardThe Children's Hospital at Westmead, Faculty of Medicine and Health, University of Sydney, Westmead, NSW, 2145, Australia.
Andrew P D HendersonDepartment of Neurology, Westmead Hospital, Westmead, NSW, 2145, Australia.
Saman HeshmatMenzies Health Institute Queensland, School of Medicine, Griffith University, Gold Coast Campus, Gold Coast, QLD, 4222, Australia.
Suzanne HodgkinsonSouth Western Sydney Medical School, Liverpool Hospital, University of New South Wales, Liverpool, NSW, 2170, Australia.
Sofia Jimenez-SanchezMenzies Health Institute Queensland, School of Medicine, Griffith University, Gold Coast Campus, Gold Coast, QLD, 4222, Australia.
Trevor J KilpatrickFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, 3010, Australia.
John KingDepartment of Neurology, Royal Melbourne Hospital, Parkville, VIC, 3010, Australia.
Chris KneeboneDepartment of Neurology, Townsville Hospital, Douglas, QLD, 4814, Australia.
Andrew J KornbergSchool of Paediatrics, Royal Children's Hospital, University of Melbourne, Parkville, VIC, 3010, Australia.
Jeannette Lechner-ScottHunter Medical Research Institute, University of Newcastle, New Lambton Heights, NSW, 2305, Australia.
Ming-Wei LinSydney Medical School, Royal Prince Alfred Hospital, University of Sydney, Camperdown, NSW, 2006, Australia.
Christopher LynchSchool of Medicine, University of Auckland, Grafton, 1142, New Zealand.
Richard A L MacdonnellDepartment of Neurology, Austin Health, Heidelberg, VIC, 3084, Australia.
Deborah F MasonDepartment of Neurology, Christchurch Hospital, Christchurch, 8140, New Zealand.
Pamela A McCombeCentre for Clinical Research, Royal Brisbane and Women's Hospital, University of Queensland, Herston, QLD, 4029, Australia.
Jennifer PereiraSchool of Medicine, University of Auckland, Grafton, 1142, New Zealand.
John D PollardSydney Medical School, Royal Prince Alfred Hospital, University of Sydney, Camperdown, NSW, 2006, Australia.
Stephen W ReddelBrain and Mind Research Institute, University of Sydney, Camperdown, NSW, 2006, Australia.
Cameron ShawSchool of Medicine, Deakin University, Waurn Ponds, VIC, 3217, Australia.
Judith SpiesSydney Medical School, Royal Prince Alfred Hospital, University of Sydney, Camperdown, NSW, 2006, Australia.
James StankovichMenzies Research Institute, University of Tasmania, Hobart, TAS, 7000, Australia.
Ian SuttonDepartment of Neurology, St Vincent's Hospital, Darlinghurst, NSW, 2010, Australia.
Steve VucicThe Children's Hospital at Westmead, Faculty of Medicine and Health, University of Sydney, Westmead, NSW, 2145, Australia.
Michael WalshDepartment of Neurology, Wellington Hospital, Newtown, 6021, New Zealand.
Richard C WongSchool of Medicine, Royal Brisbane and Women's Hospital, University of Queensland, Herston, QLD, 4029, Australia.
Eppie M YiuSchool of Paediatrics, Royal Children's Hospital, University of Melbourne, Parkville, VIC, 3010, Australia.
Michael H BarnettBrain and Mind Research Institute, University of Sydney, Camperdown, NSW, 2006, Australia.
Allan G KermodeCentre for Neuromuscular and Neurological Disorders, Queen Elizabeth II Medical Centre, University of Western Australia, Nedlands, WA, 6009, Australia.
Mark P MarriottMelbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, 3010, Australia.
John ParrattSydney Medical School, Royal Prince Alfred Hospital, University of Sydney, Camperdown, NSW, 2006, Australia.
Mark SleeFlinders Medical Centre, Flinders University, Bedford Park, SA, 5042, Australia.
Bruce V TaylorSchool of Medicine, Deakin University, Waurn Ponds, VIC, 3217, Australia.
Ernest WilloughbyDepartment of Neurology, Auckland City Hospital, Grafton, 1023, New Zealand.
Robert J WilsonDepartment of Neurology, Princess Alexandra Hospital, Wooloongabba, QLD, 4102, Australia.
Fabienne BrilotSchool of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, WA, 6009, Australia.
Angela VincentDepartment of Immunology, Pathology Queensland, Royal Brisbane and Women's Hospital, Herston, QLD, 4006, Australia.
Patrick WatersDepartment of Immunology, Pathology Queensland, Royal Brisbane and Women's Hospital, Herston, QLD, 4006, Australia.
Simon A BroadleyMenzies Health Institute Queensland, School of Medicine, Griffith University, Gold Coast Campus, Gold Coast, QLD, 4222, Australia. simon.broadley@griffith.edu.au.ORCID http://orcid.org/0000-0002-9429-4307
The University of Sydney · AUGriffith University · AUThe University of Western Australia · AUThe University of Queensland · AURoyal Brisbane and Women's Hospital · AUThe Royal Melbourne Hospital · AUAuckland City Hospital · NZDeakin University · AUFlinders University · AUPrincess Alexandra Hospital · AURoyal Children's Hospital · AUTownsville Hospital · AUUniversity of Auckland · NZWellington Hospital · NZWestmead Hospital · AUAustin Health · AUCanberra Hospital · AUChildren's Hospital at Westmead · AUChristchurch Hospital · NZDuke Kunshan University · CN

Funding

Griffith Health Institute, Griffith University n/aMultiple Sclerosis Research Australia 11-038NIHR Oxford Biomedical Research Centre n/a
6 · The paper itself

Abstract

Neuromyelitis optica spectrum disorders (NMOSD) are an inflammation of the central nervous system associated with autoantibodies to aquaporin-4. We have undertaken a clinic-based survey of NMOSD in the Australia and New Zealand populations with the aim of characterising the clinical features and establishing the value of recently revised diagnostic criteria. Cases of possible NMOSD and age and sex-matched controls with multiple sclerosis (MS) were referred from centres across Australia and New Zealand. Cases were classified as NMOSD if they met the 2015 IPND criteria and remained as suspected NMOSD if they did not. Clinical and paraclinical data were compared across the three groups. NMOSD was confirmed in 75 cases and 89 had suspected NMOSD. There were 101 controls with MS. Age at onset, relapse rates and EDSS scores were significantly higher in NMOSD than in MS. Lesions and symptoms referable to the optic nerve were more common in NMOSD whereas brainstem, cerebellar and cerebral lesions were more common in MS. Longitudinally extensive spinal cord lesions were seen in 48/71 (68%) of cases with NMOSD. Elevations of CSF, white cell count and protein were more common in NMOSD. We have confirmed a clinical pattern of NMOSD that has been seen in several geographical regions. We have demonstrated the clinical utility of the current diagnostic criteria. Distinct patterns of disease are evident in NMOSD and MS, but there remains a large number of patients with NMOSD-like features who do not meet the current diagnostic criteria for NMOSD and remain a diagnostic challenge.

Indexed as

AdultAgedAustraliaFemaleHealth SurveysHumansMaleMiddle AgedNeuromyelitis OpticaNew ZealandYoung AdultAquaporinAutoimmune diseaseClinical featuresMultiple sclerosisNeuromyelitis optica

Identifiers

PMID32006158
OpenAlexW3003481897

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.