Evidence map›Paper›PMID 32006056›Full record

ArticleEuropean biophysics journal : EBJ2020

Experimental study of the difference in deformation between normal and pathological, renal and bladder, cells induced by acoustic radiation force.

Haibin Wang, Yupei Qiao, Jiehui Liu, Bo Jiang, Gutian Zhang, Chengwei Zhang, Xiaozhou Liu

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in European biophysics journal : EBJ, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Haibin WangKey Laboratory of Modern Acoustics, Institute of Acoustics, Nanjing University, Nanjing, 210093, China.
Yupei QiaoKey Laboratory of Modern Acoustics, Institute of Acoustics, Nanjing University, Nanjing, 210093, China.
Jiehui LiuKey Laboratory of Modern Acoustics, Institute of Acoustics, Nanjing University, Nanjing, 210093, China.
Bo JiangNanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210093, China.
Gutian ZhangNanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210093, China.
Chengwei ZhangNanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 210093, China.
Xiaozhou LiuKey Laboratory of Modern Acoustics, Institute of Acoustics, Nanjing University, Nanjing, 210093, China. xzliu@nju.edu.cn.ORCID http://orcid.org/0000-0003-1923-3026
Nanjing Drum Tower Hospital · CNInstitute of Acoustics · CNChinese Academy of Sciences · CNJiangsu University of Science and Technology · CN

Funding

AQSIQ technology R&D program 2017QK125Key Laboratory of Underwater Acoustic Environment, Chinese Academy of Sciences SSHJ-KFKT-1701National key R & D program 2016YFF0203000National Natural Science Foundation of China 11774167State Key Laboratory of Acoustics, Chinese Academy of Science SKLA201809State Key Program of National Natural Science of China 11834008
6 · The paper itself

Abstract

Previous studies have shown that alterations in the mechanical properties of cells may be associated with the onset and progression of some forms of pathology. In this paper, an experimental study of two types of cells, renal (cancer) and bladder (cancer) cells, is described which used acoustic radiation force (ARF) generated by a high-frequency ultrasound focusing transducer and performed on the operating platform of an inverted light microscope. Comparing images of cancer cells with those of normal cells of the same kind, we find that the cancer cells are more prone to deform than normal cells of the same kind under the same ARF. In addition, cancer cells with higher malignancy are more deformable than those with lower malignancy. This means that the deformability of cells may be used to distinguish diseased cells from normal ones, and more aggressive cells from less aggressive ones, which may provide a more rapid and accurate method for clinical diagnosis of urological disease in the future.

Indexed as

AcousticsUltrasonicsAlgorithmsCell Line, TumorDisease ProgressionHumansKidneyKidney NeoplasmsMechanical PhenomenaTransducersUrinary BladderUrinary Bladder NeoplasmsAcoustic radiation forceBladder cellsDeformability of cellsRenal cellsUltrasound focusing transducer

Identifiers

PMID32006056
OpenAlexW3004189582

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.