Evidence map›Paper›PMID 32006045›Full record

ReviewHNO2020

Targeting CSPG4 for isolation of melanoma cell-derived exosomes from body fluids.

S Ferrone, T L Whiteside

Open access · greenAbstract readReview
In one paragraph

Review in HNO, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. MCSPNature cancer · 2025
    Article
  3. Tumor-derived Exosomes and Antitumor Immunity.Journal of immunology (Baltimore, Md. : 1950) · 2024
    Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Signaling of Tumor-Derived sEV Impacts Melanoma Progression.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

S FerroneDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, 02114, Boston, MA, USA. sferrone@mgh.harvard.edu.
T L WhitesideDepartments of Pathology, Immunology and Otolaryngology, University of Pittsburgh School of Medicine and UPMC Hillman Cancer Center, 15213, Pittsburgh, PA, USA.
Harvard University · USUPMC Hillman Cancer Center · US

Funding

Adaptive immunotherapy of anaplastic thyroid cancerR03CA239193 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI PARANGI, SAREH · 2019 to 2020
$165k
NCI NIH HHS R03 CA239193
6 · The paper itself

Abstract

This manuscript describes the functional properties of the exosomes released from melanoma cells. It details the characteristics of the tumor antigen chondroitin sulfate proteoglycan 4 (CSPG4), which is used as a marker to separate exosomes released by melanoma cells from exosomes released by nonmalignant cells. The results are discussed in view of the potential role of melanoma cell-derived exosomes in the escape of malignant cells from the host's immune system.

Indexed as

Chondroitin Sulfate ProteoglycansExosomesMelanomaMembrane ProteinsSkin NeoplasmsAntigensBiomarkersBody FluidsChondroitin Sulfate Proteoglycan 4HumansProteoglycansAntigensBiomarkersChondroitin Sulfate Proteoglycan 4Chondroitin Sulfate ProteoglycansCSPG4 protein, humanMembrane ProteinsProteoglycansAntigensExtracellular vesiclesImmune systemImmunotherapyNeoplasm

Identifiers

PMID32006045
PMCPMC8744949
OpenAlexW3003793287

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.