ArticleThe ISME journal2020
The gut microbiota response to helminth infection depends on host sex and genotype.
Article in The ISME journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 59 citations in OpenAlex.
- The Influence of Innate Immunity, Adaptive Immunity and Diet on Intestinal Microbiota Following Trichuris muris Infection.Parasite immunology · 2026Article
- Increased caecal Intestinimonas abundance inhibits E. tenella gametogenesis via EtGFAT regulation and alleviates infection through immunity.Microbiome · 2026Article
- Article
- Challenging the paradigm: the Asian fish tapeworm (Schyzocotyle acheilognathi, Yamaguti 1934) lacks an intrinsic symbiotic bacterial community.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Analyzing human gut microbiome data from global populations: challenges and resources.Trends in microbiology · 2025Review
- Co-Infection Dynamics ofInternational journal of molecular sciences · 2025Review
- Interplay between antipredator behavior, parasitism, and gut microbiome in wild stickleback populations.NPJ biofilms and microbiomes · 2025Article
- Host-Microbiota-Parasite Interactions in Grass Carp: Insights fromMicroorganisms · 2025Article
- Intestinal helminthFrontiers in microbiology · 2025Article
- Effect of ectoparasiteFrontiers in veterinary science · 2025Article
- Helminths in alternative therapeutics of inflammatory bowel disease.Intestinal research · 2025Review
- Understanding the role of microbes in health and disease of farmed aquatic organisms.Marine life science & technology · 2024Article
- The Dominance of Coinfecting Parasites' Indirect Genetic Effects on Host Traits.The American naturalist · 2024Article
- Demographic and zoological drivers of infectome diversity in companion cats with ascites.mSystems · 2024Article
- Host genotype and infection status interact to shape microbiomes inParasitology · 2024Article
- Host-gut microbiota interactions shape parasite infections in farmed Atlantic salmon.mSystems · 2024Article
- Global research trends on the links between gut microbiota and radiotherapy: a bibliometric analysis (2004-2023).Frontiers in cellular and infection microbiology · 2024Article
- Gut microbiota of an Amazonian fish in a heterogeneous riverscape: integrating genotype, environment, and parasitic infections.Microbiology spectrum · 2023Article
- Species interactions, stability, and resilience of the gut microbiota - Helminth assemblage in horses.iScience · 2023Article
- Sex-the most underappreciated variable in research: insights from helminth-infected hosts.Veterinary research · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 7 institutions in 2 countries.
Funding
Abstract
Vertebrates' gut microbial communities can be altered by the hosts' parasites. Helminths inhabiting the gut lumen can interact directly with their host's microbiota via physical contact, chemical products, or competition for nutrients. Indirect interactions can also occur, for instance when helminths induce or suppress host immunity in ways that have collateral effects on the microbiota. If there is genetic variation in host immune responses to parasites, we would expect such indirect effects to be conditional on host genotype. To test for such genotype by infection interactions, we experimentally exposed Gasterosteus aculeatus to their naturally co-evolved parasite, Schistocephalus solidus. The host microbiota differed in response to parasite exposure, and between infected and uninfected fish. The magnitude and direction of microbial responses to infection differed between host sexes, and also differed between variants at autosomal quantitative trait loci. These results indicate that host genotype and sex regulate the effect of helminth infection on a vertebrate gut microbiota. If this result holds in other taxa, especially humans, then helminth-based therapeutics for dysbiosis might need to be tailored to host genotype and sex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.