ArticleCommunications biology2020
Trypanosomatid parasite dynamically changes the transcriptome during infection and modifies honey bee physiology.
Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 59 citations in OpenAlex.
- Zombies without puppeteers: Morgan's Canon and the passive manipulation hypothesis inFrontiers in parasitology · 2026Article
- Role of ergosterol biosynthesis in growth, drug sensitivity, and host colonization of honey bee trypanosomatid parasite,FEMS microbes · 2026Article
- Chromosome-level genome assembly of trypanosomatid parasite Lotmaria passim links chromosome duplication and divergence with infection of honey bees.BMC genomics · 2025Article
- BBSome deficiency in Lotmaria passim reveals divergent functions in trypanosomatid parasites.Parasites & vectors · 2025Article
- Somy evolution in the honey bee infecting trypanosomatid parasite Lotmaria passim.G3 (Bethesda, Md.) · 2025Article
- Review
- The trypanosomatid (Kinetoplastida: Trypanosomatidae) parasites in bees: A review on their environmental circulation, impacts and implications.Current research in insect science · 2025Review
- Based proteomics analyses reveal response mechanisms of Apis mellifera (Hymenoptera: Apidae) against the heat stress.Journal of insect science (Online) · 2024Article
- Caterpillar-parasitoid interactions: species-specific influences on host microbiome composition.FEMS microbiology ecology · 2024Article
- Protein subcellular relocalization and function of duplicated flagellar calcium binding protein genes in honey bee trypanosomatid parasite.PLoS genetics · 2024Article
- Aspartyl protease in the secretome of honey bee trypanosomatid parasite contributes to infection of bees.Parasites & vectors · 2024Article
- A tale of two parasites: Responses of honey bees infected with Nosema ceranae and Lotmaria passim.Scientific reports · 2023Article
- High temperatures augment inhibition of parasites by a honey bee gut symbiont.Applied and environmental microbiology · 2023Article
- The Activity of Red Nigerian Propolis and Some of Its Components againstMolecules (Basel, Switzerland) · 2023Article
- Article
- The Epidemiological Situation of the Managed Honey Bee (Veterinary sciences · 2022Article
- Hot and sour: parasite adaptations to honeybee body temperature and pH.Proceedings. Biological sciences · 2021Article
- Conservation genomics reveals pesticide and pathogen exposure in the declining bumble bee Bombus terricola.Molecular ecology · 2021Article
- Workflow ofInternational journal for parasitology. Parasites and wildlife · 2021Article
- Genome Analysis ofGenes · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is still not understood how honey bee parasite changes the gene expression to adapt to the host environment and how the host simultaneously responds to the parasite infection by modifying its own gene expression. To address this question, we studied a trypanosomatid, Lotmaria passim, which can be cultured in medium and inhabit the honey bee hindgut. We found that L. passim decreases mRNAs associated with protein translation, glycolysis, detoxification of radical oxygen species, and kinetoplast respiratory chain to adapt to the anaerobic and nutritionally poor honey bee hindgut during the infection. After the long term infection, the host appears to be in poor nutritional status, indicated by the increase and decrease of take-out and vitellogenin mRNAs, respectively. Simultaneous gene expression profiling of L. passim and honey bee during infection by dual RNA-seq provided insight into how both parasite and host modify their gene expressions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.