Evidence map›Paper›PMID 32005876›Full record

ArticleNature communications2020

Ultracompact 3D microfluidics for time-resolved structural biology.

Juraj Knoška, Luigi Adriano, Salah Awel, Kenneth R Beyerlein, Oleksandr Yefanov, Dominik Oberthuer, Gisel E Peña Murillo, Nils Roth, Iosifina Sarrou, Pablo Villanueva-Perez and 5 more

Abstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed.

  1. Radiation damage in serial femtosecond crystallography studied in hemoglobin.Acta crystallographica. Section D, Structural biology · 2026
    Article
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  4. A Plug-and-Play Volume Minimizing Micromixer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
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  15. Article
  16. 3D printing of micro-nano devices and their applications.Microsystems & nanoengineering · 2025
    Review
  17. Article
  18. Article
  19. Article
  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Juraj KnoškaCFEL, Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0001-7258-6256
Luigi AdrianoDESY, Deutsches Elektronen-Synchrotron, Notkestrasse 85, 22607, Hamburg, Germany.
Salah AwelCFEL, Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Kenneth R BeyerleinCFEL, Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0002-7701-4369
Oleksandr YefanovCFEL, Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Dominik OberthuerCFEL, Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Gisel E Peña MurilloCFEL, Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0001-7842-4987
Nils RothCFEL, Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Iosifina SarrouCFEL, Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Pablo Villanueva-PerezCFEL, Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Max O WiedornCFEL, Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany.
Fabian WildeHelmholtz-Zentrum Geesthacht, Institut für Werkstoffforschung, Max-Planck-Straße. 1, 21502, Geesthacht, Germany.ORCID http://orcid.org/0000-0002-6080-3601
Saša BajtDESY, Deutsches Elektronen-Synchrotron, Notkestrasse 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0002-7163-7602
Henry N ChapmanCFEL, Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany. henry.chapman@cfel.de.ORCID http://orcid.org/0000-0002-4655-1743
Michael HeymannCFEL, Center for Free-Electron Laser Science, Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607, Hamburg, Germany. michael.heymann@bio.uni-stuttgart.de.ORCID http://orcid.org/0000-0002-9278-8207

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To advance microfluidic integration, we present the use of two-photon additive manufacturing to fold 2D channel layouts into compact free-form 3D fluidic circuits with nanometer precision. We demonstrate this technique by tailoring microfluidic nozzles and mixers for time-resolved structural biology at X-ray free-electron lasers (XFELs). We achieve submicron jets with speeds exceeding 160 m s

Indexed as

HemeHemoglobinsHumansLasersMicrofluidicsPrinting, Three-DimensionalSynthetic BiologyX-Ray MicrotomographyHemeHemoglobins

Identifiers

PMID32005876
PMCPMC6994545

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.