Evidence map›Paper›PMID 32005766›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020

Integration of Hypernatremia and Angiotensin II by the Organum Vasculosum of the Lamina Terminalis Regulates Thirst.

Brian J Kinsman, Sarah S Simmonds, Kirsteen N Browning, Megan M Wenner, William B Farquhar, Sean D Stocker

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Body fluid regulation.Current opinion in neurobiology · 2025
    Review
  5. The biology of water homeostasis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Review
  6. Review
  7. Article
  8. Review
  9. Fluid transitions.Neuropharmacology · 2024
    Review
  10. Optogenetics in oral and craniofacial research.Journal of Zhejiang University. Science. B · 2024
    Review
  11. Homeostatic Signal Convergence in Vagal Baroreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Review
  12. Thirst: neuroendocrine regulation in mammals.Veterinary research communications · 2023
    Review
  13. Article
  14. Review
  15. Article
  16. Central regulation of body fluid homeostasis.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2022
    Review
  17. Review
  18. Review
  19. SLC9A4 in the organum vasculosum of the lamina terminalis is a [NaPflugers Archiv : European journal of physiology · 2020
    Article
  20. Akinetic Mutism and Coronavirus Disease 2019: A Narrative Review.Journal of the Academy of Consultation-Liaison Psychiatry
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Brian J KinsmanDivision of Renal-Electrolyte, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213.
Sarah S SimmondsDepartment of Neural and Behavioral Sciences, Penn State College of Medicine, Hershey, Pennsylvania 17033, and.
Kirsteen N BrowningDepartment of Neural and Behavioral Sciences, Penn State College of Medicine, Hershey, Pennsylvania 17033, and.
Megan M WennerDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware 19713.
William B FarquharDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware 19713.
Sean D StockerDivision of Renal-Electrolyte, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, stockers@pitt.edu.ORCID 0000-0001-6317-6300
Pennsylvania State University · USUniversity of Delaware · USUniversity of Pittsburgh · US

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI APODACA, GERARD L · 2008 to 2022
$13.4M
Adverse Neurogenic Actions of Dietary SaltR01HL128388 · NHLBI · UNIVERSITY OF DELAWARE · PI FARQUHAR, WILLIAM B, STOCKER, SEAN D · 2016 to 2019
$2.6M
Identification of mechano versus chemo-sensitive renal sensory neurons in hypertensionR01HL152680 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STOCKER, SEAN D · 2020 to 2023
$2.4M
Brain NaCl-sensing in salt-sensitive hypertension.R01HL145875 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STOCKER, SEAN D · 2019 to 2022
$2.2M
Central Osmosensory Mechanisms in Salt-Sensitive HypertensionR01HL113270 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STOCKER, SEAN D · 2013 to 2016
$1.5M
Brain ENaC and sodium-sensing in salt-sensitive hypertensionF30HL131269 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KINSMAN, BRIAN J · 2016 to 2019
$144k
NHLBI NIH HHS F30 HL131269NHLBI NIH HHS R01 HL113270NHLBI NIH HHS R01 HL128388NHLBI NIH HHS R01 HL145875NHLBI NIH HHS R01 HL152680NIDDK NIH HHS P30 DK079307
6 · The paper itself

Abstract

The organum vasculosum of the lamina terminalis (OVLT) contains NaCl-sensitive neurons to regulate thirst, neuroendocrine function, and autonomic outflow. The OVLT also expresses the angiotensin II (AngII) type1 receptor, and AngII increases Fos expression in OVLT neurons. The present study tested whether individual OVLT neurons sensed both NaCl and AngII to regulate thirst and body fluid homeostasis. A multifaceted approach, including

Indexed as

Angiotensin IIAnimalsHypernatremiaMaleNeuronsOrganum VasculosumRatsRats, Sprague-DawleySodium ChlorideThirstWater-Electrolyte BalanceAngiotensin IISodium Chlorideangiotensin IIhypothalamussalt appetitesodiumthirst

Identifiers

PMID32005766
PMCPMC7055145
OpenAlexW3003338488

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.