Evidence map›Paper›PMID 32005698›Full record

ArticleJournal of cell science2020

Retrograde signaling mediates an adaptive survival response to endoplasmic reticulum stress in

Imadeddin Hijazi, Jeffrey Knupp, Amy Chang

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cell science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.7field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  11. Targeting the Ubiquitin-Proteasome System Using the UBA1 Inhibitor TAK-243 is a Potential Therapeutic Strategy for Small-Cell Lung Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Article
  12. Article
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  15. Microorganisms · 2021
    Article
  16. Article
  17. Article
  18. Aeration mitigates endoplasmic reticulum stress inMicrobial cell (Graz, Austria) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Imadeddin HijaziDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, 1105 N University, Ann Arbor, MI 48109, USA.
Jeffrey KnuppDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, 1105 N University, Ann Arbor, MI 48109, USA.
Amy ChangDepartment of Molecular, Cellular and Developmental Biology, University of Michigan, 1105 N University, Ann Arbor, MI 48109, USA amychang@umich.edu.ORCID 0000-0003-3682-6456
University of Michigan · US

Funding

Cell survival after ER stressR21AG058862 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHANG, AMY Y · 2019 to 2020
$409k
NIA NIH HHS R21 AG058862
6 · The paper itself

Abstract

One major cause of endoplasmic reticulum (ER) stress is homeostatic imbalance between biosynthetic protein folding and protein folding capacity. Cells utilize mechanisms such as the unfolded protein response (UPR) to cope with ER stress. Nevertheless, when ER stress is prolonged or severe, cell death may occur, accompanied by production of mitochondrial reactive oxygen species (ROS). Using a yeast model (

Indexed as

Endoplasmic Reticulum StressSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsEndoplasmic ReticulumUnfolded Protein ResponseSaccharomyces cerevisiae ProteinsEndoplasmic reticulumER stressMitochondriaYeast

Identifiers

PMID32005698
PMCPMC7132770
OpenAlexW3004338432

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.