Evidence map›Paper›PMID 32005660›Full record

ArticleThe Journal of biological chemistry2020

Structural basis for interorganelle phospholipid transport mediated by VAT-1.

Yasunori Watanabe, Yasushi Tamura, Chika Kakuta, Seiya Watanabe, Toshiya Endo

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Target gene regulatory network of miR-497 in angiosarcoma.bioRxiv : the preprint server for biology · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Yasunori WatanabeDepartment of Bioscience, Graduate School of Agriculture, Ehime University, Matsuyama, Ehime 790-8566, Japan; Faculty of Life Sciences, Kyoto Sangyo University, Kamigamo-Motoyama, Kita-ku, Kyoto 603-8555, Japan.
Yasushi TamuraDepartment of Material and Biological Chemistry, Faculty of Science, Yamagata University, Yamagata 990-8560, Japan.
Chika KakutaFaculty of Life Sciences, Kyoto Sangyo University, Kamigamo-Motoyama, Kita-ku, Kyoto 603-8555, Japan.
Seiya WatanabeDepartment of Bioscience, Graduate School of Agriculture, Ehime University, Matsuyama, Ehime 790-8566, Japan; Center for Marine Environmental Studies, Ehime University, Matsuyama, Ehime 790-8577, Japan.
Toshiya EndoFaculty of Life Sciences, Kyoto Sangyo University, Kamigamo-Motoyama, Kita-ku, Kyoto 603-8555, Japan; Research Center for Protein Dynamics, Kyoto Sangyo University, Kamigamo-Motoyama, Kita-ku, Kyoto 603-8555, Japan. Electronic address: tendo@cc.kyoto-su.ac.jp.
Kyoto Sangyo University · JPEhime University · JPYamagata University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eukaryotic cells are compartmentalized to form organelles, whose functions rely on proper phospholipid and protein transport. Here we determined the crystal structure of human VAT-1, a cytosolic soluble protein that was suggested to transfer phosphatidylserine, at 2.2 Å resolution. We found that VAT-1 transferred not only phosphatidylserine but also other acidic phospholipids between membranes

Indexed as

Binding SitesBiological TransportCrystallography, X-RayHumansLiposomesMolecular Dynamics SimulationMutagenesis, Site-DirectedPhosphatidylserinesPhospholipidsProtein DomainsProtein Structure, TertiaryTryptophanVesicular Transport ProteinsLiposomesPhosphatidylserinesPhospholipidsTryptophanVAT1 protein, humanVesicular Transport Proteinsendoplasmic reticulum (ER)lipid-protein interactionlipid transportmitochondriaX-ray crystallography

Identifiers

PMID32005660
PMCPMC7062155
OpenAlexW3004024735

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.