ArticleThe Journal of biological chemistry2020
Structure-function relationships of the soluble form of the antiaging protein Klotho have therapeutic implications for managing kidney disease.
Open access · hybridAbstract read
In one paragraph
Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- GWAS meta-analysis followed by Mendelian randomization revealed potential control mechanisms for circulating α-Klotho levels.Human molecular genetics · 2022Pooled it
- Pharmaceutical Strategies for Translating Klotho-Based Therapeutics: From Biologic Developability to Advanced Delivery Systems.Pharmaceutics · 2026Review
- Klotho deficiency and cognitive impairment in dialysis patients: mechanisms, clinical evidence, and therapeutic implications.Frontiers in aging neuroscience · 2026Review
- A Robust, High-Titer, Semi-Automated, and In-Culture Antibody-Capturing Transient CHO Platform Technology.Antibodies (Basel, Switzerland) · 2025Article
- Conformational landscape of soluble α-klotho revealed by cryogenic electron microscopy.Scientific reports · 2025Article
- Systemic immunoinflammatory indexes in albuminuric adults are negatively associated with α-klotho: evidence from NHANES 2007-2016.Renal failure · 2024Article
- Asparagine614 Determines the Transport and Function of the Murine Anti-Aging Protein Klotho.Cells · 2024Article
- Klotho: A Large Protein with Various Beneficial Functions, but also with Therapeutic Value?Journal of the American Society of Nephrology : JASN · 2024Article
- The Urinary Glycopeptide Profile Differentiates Early Cardiorenal Risk in Subjects Not Meeting Criteria for Chronic Kidney Disease.International journal of molecular sciences · 2024Article
- Conformational landscape of soluble α-klotho revealed by cryogenic electron microscopy.bioRxiv : the preprint server for biology · 2024Article
- Klotho: a potential therapeutic target in aging and neurodegeneration beyond chronic kidney disease-a comprehensive review from the ERA CKD-MBD working group.Clinical kidney journal · 2024Article
- Relationships between serum Klotho concentrations and cognitive performance among older chronic kidney disease patients with albuminuria in NHANES 2011-2014.Frontiers in endocrinology · 2023Article
- New Opportunities in Glycan Engineering for Therapeutic Proteins.Antibodies (Basel, Switzerland) · 2022Review
- The controversy of klotho as a potential biomarker in chronic kidney disease.Frontiers in pharmacology · 2022Review
- Mass spectrometry-based N-glycosylation analysis in kidney disease.Frontiers in molecular biosciences · 2022Review
- Pathobiology of the Klotho Antiaging Protein and Therapeutic Considerations.Frontiers in aging · 2022Review
- Abnormally decreased renal Klotho is linked to endoplasmic reticulum-associated degradation in mice.International journal of medical sciences · 2022Article
- Klotho and calciprotein particles as therapeutic targets against accelerated ageing.Clinical science (London, England : 1979) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors at 1 institution in 1 country.
Xiaotian ZhongBioMedicine Design, Pfizer Worldwide Research, Cambridge, Massachusetts 02139. Electronic address: Xiaotian.Zhong@pfizer.com.
Srinath JagarlapudiInternal Medicine, Pfizer Worldwide Research, Cambridge, Massachusetts 02139.
Yan WengBioMedicine Design, Pfizer Worldwide Research, Cambridge, Massachusetts 02139.
Mellisa LyAnalytical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Andover, Massachusetts 01810.
Jason C RouseAnalytical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Andover, Massachusetts 01810.
Kim McClureInternal Medicine, Pfizer Worldwide Research, Cambridge, Massachusetts 02139.
Tetsuya IshinoBioMedicine Design, Pfizer Worldwide Research, Cambridge, Massachusetts 02139.
Yan ZhangBioMedicine Design, Pfizer Worldwide Research, Cambridge, Massachusetts 02139.
Eric SousaBioMedicine Design, Pfizer Worldwide Research, Cambridge, Massachusetts 02139.
Justin CohenBioMedicine Design, Pfizer Worldwide Research, Cambridge, Massachusetts 02139.
Boriana TzvetkovaAnalytical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Andover, Massachusetts 01810.
Kaffa CoteAnalytical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Andover, Massachusetts 01810.
John J ScarcelliCell Line Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Andover, Massachusetts 01810.
Keith JohnsonAnalytical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Andover, Massachusetts 01810.
Joe PalandraBioMedicine Design, Pfizer Worldwide Research, Cambridge, Massachusetts 02139.
James R ApgarBioMedicine Design, Pfizer Worldwide Research, Cambridge, Massachusetts 02139.
Suma YaddanapudiInternal Medicine, Pfizer Worldwide Research, Cambridge, Massachusetts 02139.
Romer A Gonzalez-VillalobosInternal Medicine, Pfizer Worldwide Research, Cambridge, Massachusetts 02139.
Alan C OpsahlInternal Medicine, Pfizer Worldwide Research, Cambridge, Massachusetts 02139.
Khetemenee LamBioMedicine Design, Pfizer Worldwide Research, Cambridge, Massachusetts 02139.
Qing YaoBioMedicine Design, Pfizer Worldwide Research, Cambridge, Massachusetts 02139.
Weili DuanBioMedicine Design, Pfizer Worldwide Research, Cambridge, Massachusetts 02139.
Annette SieversBioMedicine Design, Pfizer Worldwide Research, Cambridge, Massachusetts 02139.
Jing ZhouBioMedicine Design, Pfizer Worldwide Research, Cambridge, Massachusetts 02139.
Darren FergusonBioMedicine Design, Pfizer Worldwide Research, Cambridge, Massachusetts 02139.
Aaron D'AntonaBioMedicine Design, Pfizer Worldwide Research, Cambridge, Massachusetts 02139.
Richard ZollnerBioMedicine Design, Pfizer Worldwide Research, Cambridge, Massachusetts 02139.
Hongli L ZhuBioMedicine Design, Pfizer Worldwide Research, Cambridge, Massachusetts 02139.
Ron KrizBioMedicine Design, Pfizer Worldwide Research, Cambridge, Massachusetts 02139.
Laura LinBioMedicine Design, Pfizer Worldwide Research, Cambridge, Massachusetts 02139.
Valerie ClerinInternal Medicine, Pfizer Worldwide Research, Cambridge, Massachusetts 02139. Electronic address: Valerie.Clerin@pfizer.com.
Pfizer (United States) · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fortuitously discovered antiaging membrane protein αKlotho (Klotho) is highly expressed in the kidney, and deletion of the
Indexed as
AnimalsCatalytic DomainCHO CellsChromatography, High Pressure LiquidCricetinaeCricetulusFibroblast Growth Factor-23Glomerular Filtration RateGlucuronidaseGlycopeptidesHalf-LifeHEK293 CellsHumansKlotho ProteinsMass SpectrometryMutagenesis, Site-DirectedFGF23 protein, humanFgf23 protein, mouseFibroblast Growth Factor-23GlucuronidaseGlycopeptidesKlotho ProteinsRecombinant Proteinsacute kidney injuryfibroblast growth factor receptor (FGFR)glycosidaseglycosylationKlothoLacdiNAcmammalian cell expressionpharmacokineticssialic acidsignal transduction
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.