Evidence map›Paper›PMID 32005194›Full record

Observational studyBMC pregnancy and childbirth2020

Gestational diabetes and the human salivary microbiota: a longitudinal study during pregnancy and postpartum.

Mie K W Crusell, Lærke R Brink, Trine Nielsen, Kristine H Allin, Torben Hansen, Peter Damm, Jeannet Lauenborg, Tue H Hansen, Oluf Pedersen

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC pregnancy and childbirth, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

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  18. Metabarcoding analysis of oral microbiome during pregnancy.Frontiers in cellular and infection microbiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Mie K W CrusellNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Human Genomics and Metagenomics in Metabolism, University of Copenhagen, Blegdamsvej 3B 8th floor, 2200, Copenhagen N, Denmark. mie.wiinblad@sund.ku.dk.ORCID http://orcid.org/0000-0003-0144-7472
Lærke R BrinkNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Human Genomics and Metagenomics in Metabolism, University of Copenhagen, Blegdamsvej 3B 8th floor, 2200, Copenhagen N, Denmark.
Trine NielsenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Human Genomics and Metagenomics in Metabolism, University of Copenhagen, Blegdamsvej 3B 8th floor, 2200, Copenhagen N, Denmark.
Kristine H AllinNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Human Genomics and Metagenomics in Metabolism, University of Copenhagen, Blegdamsvej 3B 8th floor, 2200, Copenhagen N, Denmark.
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Human Genomics and Metagenomics in Metabolism, University of Copenhagen, Blegdamsvej 3B 8th floor, 2200, Copenhagen N, Denmark.
Peter DammDepartment of Obstetrics, Center for Pregnant Women with Diabetes, Rigshospitalet University Hospital, Blegdamsvej 9, 2100, Copenhagen Ø, Denmark.
Jeannet LauenborgDepartment for Gynecology and Obstetrics, Herlev University Hospital, Herlev Ringvej 75, 2730, Herlev, Denmark.
Tue H HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Human Genomics and Metagenomics in Metabolism, University of Copenhagen, Blegdamsvej 3B 8th floor, 2200, Copenhagen N, Denmark.
Oluf PedersenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Human Genomics and Metagenomics in Metabolism, University of Copenhagen, Blegdamsvej 3B 8th floor, 2200, Copenhagen N, Denmark.
University of Copenhagen · DKHerlev Hospital · DK

Funding

Aase og Ejnar Danielsens Fond 10-001605Augustinus Fonden 13-4608
6 · The paper itself

Abstract

backgroundAn aberrant composition of the salivary microbiota has been found in individuals with type 2 diabetes, and in pregnant women salivary microbiota composition has been associated with preeclampsia and pre-term birth. Pregnant women, who develop gestational diabetes (GDM), have a high risk of developing type 2 diabetes after pregnancy. In the present study we assessed whether GDM is linked to variation in the oral microbial community by examining the diversity and composition of the salivary microbiota.

methodIn this observational study the salivary microbiota of pregnant women with GDM (n = 50) and normal glucose regulation (n = 160) in third trimester and 9 months postpartum was assessed by 16S rRNA gene amplicon sequencing of the V1-V3 region. GDM was diagnosed in accordance with the International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria. Cross-sectional difference in alpha diversity was assessed using Student's t-test and longitudinal changes were assessed by mixed linear regression. Cross-sectional and longitudinal difference in beta diversity was assessed by permutational multivariate analyses of variance. Differentially abundant genera and OTUs were identified by negative binomial regression.

resultsIn the third trimester, two species-level operational taxonomic units (OTUs), while eight OTUs postpartum were differentially abundant in women with GDM compared with normoglycaemic women. OTU richness, Shannon diversity and Pielou evenness decreased from late pregnancy to 9 months after delivery regardless of glycaemic status.

conclusionGDM is associated with a minor aberration of the salivary microbiota during late pregnancy and postpartum. For unknown reasons richness of the salivary microbiota decreased from late pregnancy to postpartum, which might be explained by the physiological changes of the immune system during human pregnancy.

Indexed as

MicrobiotaAdultBlood GlucoseBody Mass IndexDiabetes, GestationalFemaleGlucose Tolerance TestHumansLongitudinal StudiesPostpartum PeriodPregnancyPregnancy Trimester, ThirdRNA, Ribosomal, 16SSalivaBlood GlucoseRNA, Ribosomal, 16SBacterial speciesGestational diabetes mellitusGestational hyperglycaemiaGlycaemic traitsPregnancySalivary microbiota

Identifiers

PMID32005194
PMCPMC6995204
OpenAlexW3006752919

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.