Evidence map›Paper›PMID 32005185›Full record

ArticleBMC neurology2020

Prevalence of and characteristics associated with in-hospital mortality in a Ugandan neurology ward.

Monica M Diaz, Xin Hu, Brenda T Fenton, Ivan Kimuli, Allison Lee, Hayley Lindsey, Jeffrey K Bigelow, Samuel Maiser, Hamada H Altalib, Jason J Sico

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in BMC neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04322162 (Addressing Sleep Apnea Post-Stroke), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04322162 naunknown statusnot on this map

Addressing Sleep Apnea Post-Stroke (ASAP)

TypeinterventionalSponsorVA Office of Research and DevelopmentRan2020 to 2024Enrolled6ConditionsIschemic Stroke, Transient Ischemic Attack (TIA), Obstructive Sleep ApneaArmsASAP Intervention Quality Improvement Protocol
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Monica M DiazDepartment of Neurosciences, University of California San Diego, 220 Dickinson Street, Mail Code 8231, San Diego, CA, 92103, USA. mmdiaz@health.ucsd.edu.ORCID http://orcid.org/0000-0001-9663-5948
Xin HuYale Center for Analytical Science, Yale School of Public Health, New Haven, CT, USA.
Brenda T FentonChronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.
Ivan KimuliMulago Hospital and Makerere University, Kampala, Uganda.
Allison LeePain Research, Informatics, and Multi-morbidities, and Education (PRIME) Center, VA Connecticut Healthcare System, West Haven, CT, USA.
Hayley LindseyPain Research, Informatics, and Multi-morbidities, and Education (PRIME) Center, VA Connecticut Healthcare System, West Haven, CT, USA.
Jeffrey K BigelowIntermountain Medical Center, Salt Lake City, UT, USA.
Samuel MaiserDepartments of Neurology and Internal Medicine, University of Minnesota, Minneapolis, MN, USA.
Hamada H AltalibPain Research, Informatics, and Multi-morbidities, and Education (PRIME) Center, VA Connecticut Healthcare System, West Haven, CT, USA.
Jason J SicoChronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.
Yale University · USVA Connecticut Healthcare System · USIntermountain Medical Center · USJohnson & Johnson (United States) · USMulago Hospital · UGUniversity of Minnesota · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
University of California Launching Future Leaders in Global Health Research Training ProgramD43TW009343 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CRAIG R COHEN, Sung-Jae Lee · 2017 to 2026
$14.7M
San Diego Resource Center for advancing Alzheimer's Research in Minority Seniors (ARMS)P30AG059299 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOHN P. ELDER, PAUL E GILBERT · 2018 to 2026
$7.4M
Interdisciplinary Research Fellowship in NeuroAIDSR25MH081482 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MARIANA CHERNER · 2007 to 2026
$5.2M
FIC NIH HHS D43 TW009343NCATS NIH HHS UL1 TR001863NIA NIH HHS P30 AG059299NIMH NIH HHS R25 MH081482Office of Academic Affiliations, Department of Veterans Affairs HSRD CDA 1 IK2 HX001388-01A1UCB US None
6 · The paper itself

Abstract

backgroundWhile the burden of neurologic illness in developing countries is increasing, less is known about mortality among patients admitted to sub-Saharan African hospitals with neurologic disease. We sought to characterize the rate and patient-level predictors of in-hospital mortality in a Ugandan Neurology ward.cc.

methodsData was prospectively collected on 335 patients admitted to the Neurology ward of Mulago Hospital, Kampala, Uganda. Kaplan-Meier survival curves and multivariate COX proportional hazard modeling were used to assess survival.

resultsWithin our sample (n = 307), 35.8% received no diagnosis at time of hospital admission. Stroke (27.3%), head trauma (19.6%), and malaria (16.0%) were the most common diagnoses. Among the 56 (18.5%) patients who died during the index hospitalization, the most common diagnosis at admission and at death was stroke. Adjusted regression analysis showed that patients without a diagnosis at time of death (HR = 7.01 [2.42-20.35], p < .001) and those with diagnoses of infections (HR = 5.21 [2.16-12.58], p = <.001), stroke (HR = 2.69 [1.20-6.04], p = .017), or head trauma (HR = 3.39, [1.27-9.07], p = 0.15) had worse survival.

conclusionsIn-hospital mortality affected nearly 20% of the cohort, with worse survival among those without a diagnosis and with infections, stroke, head trauma. Future work should identify reasons for increased mortality among these high-risk groups and implement targeted interventions.

Indexed as

Hospital MortalityAdultAgedCohort StudiesFemaleHumansKaplan-Meier EstimateMaleMiddle AgedNervous System DiseasesNeurologyPrevalenceProportional Hazards ModelsUgandaGlobal neurologyHead traumaNeurological illnessNeurological infectionsStrokeUganda

Identifiers

PMID32005185
PMCPMC6995141
OpenAlexW3008571887

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.