Evidence map›Paper›PMID 32005136›Full record

ArticleBMC infectious diseases2020

Identification of subclinical tuberculosis in household contacts using exposure scores and contact investigations.

Gry Klouman Bekken, Christian Ritz, Sumithra Selvam, Nelson Jesuraj, Anneke C Hesseling, T Mark Doherty, Harleen M S Grewal, Mario Vaz, Synne Jenum

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Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Subclinical tuberculosis: a meta-analysis of prevalence and scoping review of definitions, prevalence and clinical characteristics.European respiratory review : an official journal of the European Respiratory Society · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gry Klouman BekkenDepartment of Clinical Science, Faculty of Medicine, University of Bergen, Bergen, Norway.
Christian RitzDepartment of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
Sumithra SelvamDivision of Epidemiology, Biostatistics and Population Health, St. John's Research Institute, Koramangala, Bangalore, 560 034, India.
Nelson JesurajPaediatrics and Neonatology, Trinity hospital, Palakkad, Kerala, India.
Anneke C HesselingDepartment of Pediatrics and Child Health, Desmond Tutu TB Center, Stellenbosch University, Cape Town, South Africa.
T Mark DohertyGlaxoSmithKline Vaccines Wavre, Wavre, Belgium.
Harleen M S GrewalDepartment of Clinical Science, Faculty of Medicine, University of Bergen, Bergen, Norway.
Mario VazDivision of Health and Humanities, St. John's Research Institute, Koramangala, Bangalore, 560 034, India.
Synne JenumDepartment of Clinical Science, Faculty of Medicine, University of Bergen, Bergen, Norway. synnejenum@gmail.com.ORCID http://orcid.org/0000-0001-8187-775X

Funding

Norges Forskningsråd 179342 and 192534St John's Research Institute salaries and lab supportUniversitetet i Bergen salaries
6 · The paper itself

Abstract

backgroundThe goal of tuberculosis elimination put forward in the End TB Strategy prioritizes diagnosis and treatment of incipient and subclinical TB, recently defined by key stakeholders as "asymptomatic, early pre-clinical disease during which pathology evolves". Regarded as indicative of a high risk of TB progression, considerable efforts have been made to identify these cases through exploration of biomarkers. The present study aimed to evaluate simple scoring systems for TB exposure as screening tools for subclinical TB, the only identifiable of the incipient and subclinical disease states, in a contact investigation (CI) setting of low HIV-prevalence.

methodsNested within a large prospective study in household contacts (HHCs) of smear positive pulmonary TB cases in South-India conducted 2010-2012, we assessed 1) the association between the Tuberculosis Contact Score (TCS) and the Infectivity Score, with established tools for Mycobacterium tuberculosis (Mtb) infection, corrected for established TB risk factors, and 2) the capability of the TB exposure scores to identify subclinical TB defined by Mtb-culture positivity in sputum or gastric aspirate (subjects < 5 years) specimen.

resultsOf 525 HHCs, 29 were Mtb-culture positive and 96.6% of these asymptomatic. The TCS and the Infectivity Score associated with positive Tuberculin Skin Test and QuantiFeron TB-Gold In-tube assay (QFT) results in multivariate analyses (TCS: OR

conclusionsAlthough our results did not identify an easily applicable screening tool for subclinical TB, the present study indicates that focusing on TB-related symptoms in CI settings may be of limited value for early identification of HHCs with high risk for TB progression.

Indexed as

AdolescentAdultChildChild, PreschoolCross-Sectional StudiesFamily CharacteristicsFemaleHumansIndiaLatent TuberculosisMaleMass ScreeningMiddle AgedMultivariate AnalysisProspective StudiesRisk FactorsCohort studiesPoint scoring systemsPreventionPulmonary tuberculosisRisk assessmentTransmission

Identifiers

PMID32005136
PMCPMC6995184

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.