ArticlePediatric research2020
Association between dopamine and cerebral autoregulation in preterm neonates.
Article in Pediatric research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Identifying the risk factors of autism spectrum disorders in infants born preterm: a systematic review and meta-analysis.European child & adolescent psychiatry · 2026Pooled it
- Cerebrovascular autoregulation and preterm brain injury: a systematic review and meta-analysis.Pediatric research · 2025Pooled it
- Effect of delayed cord clamping and cord milking on cerebral oxygenation and cardiovascular function: a secondary analysis of the PCI trial.European journal of pediatrics · 2026Trial
- Monitoring of cerebral autoregulation during major surgery in adults, including cardiac surgery: mechanisms, anesthetic impacts, and clinical applications.Frontiers in medicine · 2026Review
- Physiology-guided vasoactive therapy in neonates: rethinking dopamine as first-line.Journal of perinatology : official journal of the California Perinatal Association · 2025Review
- Systemic hypotension and patterns of cerebral blood perfusion in newborns.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Cerebral near-infrared spectroscopy guided neonatal intensive care management for the preterm infant.Pediatric research · 2024Review
- Cerebral autoregulation in pediatric and neonatal intensive care: A scoping review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Association between early echocardiography screening of low systemic blood flow and intraventricular hemorrhage in preterm infants: a multicenter cohort study.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Near-infrared spectroscopy monitoring of neonatal cerebrovascular reactivity: where are we now?Pediatric research · 2024Review
- Dopamine or norepinephrine for sepsis-related hypotension in preterm infants: a retrospective cohort study.European journal of pediatrics · 2023Article
- Early Cerebrovascular Autoregulation in Neonates with Congenital Heart Disease.Children (Basel, Switzerland) · 2022Article
- Blood pressure values and hypotension management in extremely preterm infants: a multi-center study.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Clinical determinants of cerebrovascular reactivity in very preterm infants during the transitional period.Pediatric research · 2022Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo test the hypothesis that dopamine is associated with impaired cerebral autoregulation (ICA) in a dose-dependent fashion.
methodsNon a priori designed secondary analysis of a prospectively enrolled cohort study subjects <12 h of life between 24
resultsTwenty-three of 61 subjects (38%) required dopamine. Time spent with ICA was 23% in dopamine-exposed subjects vs. 14% in those not exposed (p = 0.0001). On the epoch level, time spent with ICA was 15%, 29%, 34%, 37%, and 23% in epochs with dopamine titration of 0, 1-5, 6-10, 11-15, and 16-20 μg/kg/min, respectively. Using mixed-effect modeling, ICA for each dopamine titration was significantly higher than unexposed times when controlling for gestation, presence of a patent ductus arteriosus, day of life, MAP less than gestational age, and illness severity score (p < 0.02).
conclusionsDopamine exposure during the first 96 h was associated with ICA. Time periods with ICA increased with dopamine exposure in a dose-dependent fashion peaking at a concentration of 11-15 μg/kg/min.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.