ArticleThe journal of allergy and clinical immunology. In practice2020
A Slice of Food Protein-Induced Enterocolitis Syndrome (FPIES): Insights from 441 Children with FPIES as Provided by Caregivers in the International FPIES Association.
Article in The journal of allergy and clinical immunology. In practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- A Systematic Review of Food Protein-Induced Enterocolitis Syndrome.International archives of allergy and immunology · 2023Pooled it
- Oral food challenges in FPIES: A narrative review and proposals for emergency and home-based management of acute FPIES reaction.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Review
- Food protein-induced enterocolitis syndrome in children: An updated review on pathogenesis, diagnosis, and management.World journal of clinical pediatrics · 2026Review
- Association of myeloid cell reactivity patterns with safe food predictions in FPIES patients.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2025Article
- Factors influencing the natural history of non-IgE-mediated gastrointestinal food allergies in paediatric age: a prospective multicentre cohort study.BMJ paediatrics open · 2025Article
- L'allergie aux protéines du lait de vache chez les nourrissons et les enfants.Paediatrics & child health · 2024Review
- Cow's milk protein allergy in infants and children.Paediatrics & child health · 2024Review
- IgE-Mediated and Non-IgE-Mediated Fish Allergy in Pediatric Age: A Holistic Approach-A Consensus by Diagnostic Commission of the Italian Society of Pediatric Allergy and Immunology.Medicina (Kaunas, Lithuania) · 2023Review
- Food protein-induced enterocolitis syndrome in an infant triggered by prunes.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023Article
- Recent Update in Food Protein-Induced Enterocolitis Syndrome: Pathophysiology, Diagnosis, and Management.Allergy, asthma & immunology research · 2022Review
- Remission of Acute Food Protein-Induced Enterocolitis Syndrome Confirmed by Oral Food Challenges in Japan.Nutrients · 2022Article
- Update on Food Protein-Induced Enterocolitis Syndrome (FPIES).Current allergy and asthma reports · 2022Review
- Adherence to dietary prescriptions in patients with acute food protein-induced enterocolitis syndrome.Pediatric investigation · 2022Article
- Predictors of initial oral food challenge outcome in food protein-induced enterocolitis syndrome.The journal of allergy and clinical immunology. Global · 2022Article
- Food protein-induced enterocolitis syndrome: A large French multicentric experience.Clinical and translational allergy · 2022Article
- Histopathology of intestinal villi in neonatal and paediatric age: main features with clinical correlation - Part II.Pathologica · 2022Review
- Alternative Fish Species for Nutritional Management of Children with Fish-FPIES-A Clinical Approach.Nutrients · 2021Review
- The evolution of food protein-induced enterocolitis syndrome: From a diagnosis that did not exist to a condition in need of answers.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2021Review
- Pathophysiology of Non-IgE-Mediated Food Allergy.ImmunoTargets and therapy · 2021Review
- The Importance of Metabolism for Immune Homeostasis in Allergic Diseases.Frontiers in immunology · 2021Review
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundFood protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated gastrointestinal food allergy. There is little known about the demographic characteristics, food triggers, and risk factors for FPIES.
objectiveTo characterize the demographic characteristics, food triggers, risk factors, and management in children with FPIES.
methodsWe retrospectively analyzed surveys completed by 410 caregiver-members of the International FPIES Association, both at a conference for families affected by FPIES and online.
resultsMost of the children were female (50.7%), white (86.2%), and atopic (54.8%), with a median age of 2 years (ranging from 2 months to 19 years). The most common food groups avoided were grains (60.0%), cow's milk (52.4%), vegetables (42.7%), and fruits (38.0%). Avocado was the most commonly avoided fruit. Avoiding avocado was associated with increased likelihood of avoiding banana (P < .001). Of these children, 69.4% avoided at least 2 food groups because of FPIES, and 20.3% had a first-degree relative with FPIES. Having a first-degree relative with FPIES was associated with increased likelihood of avoiding multiple food groups (P = .035).
conclusionsThe most common food group avoided was grains, consistent with recent literature. Avocado avoidance was higher than previously reported, and this is the first report of an association between avocado and banana avoidance in FPIES. Avoiding multiple food groups because of FPIES was more common than previously reported. A large proportion of children in our cohort had first-degree relatives with FPIES, and, furthermore, having a first-degree relative with FPIES was significantly associated with the affected child avoiding multiple food groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.