ArticleMolecular and cellular endocrinology2020
Associations of maternal diet and placenta leptin methylation.
Article in Molecular and cellular endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- The Impact of Lifestyle, Diet and Physical Activity on Epigenetic Changes in the Offspring-A Systematic Review.Nutrients · 2021Pooled it
- Review
- Epigenetic and immunological alterations in umbilical cord blood of overweight/obese women with gestational diabetes mellitus: insights into DNA methylation signatures and immune cell dysregulation.BMC pregnancy and childbirth · 2026Article
- Investigating Leptin Gene Variants and Methylation Status in Relation to Breastfeeding and Preventing Obesity.Children (Basel, Switzerland) · 2024Article
- Exploring Maternal Diet-Epigenetic-Gut Microbiome Crosstalk as an Intervention Strategy to Counter Early Obesity Programming.Current issues in molecular biology · 2024Review
- Methylation profiles at birth linked to early childhood obesity.Journal of developmental origins of health and disease · 2024Article
- Molecular pathways in placental-fetal development and disruption.Molecular and cellular endocrinology · 2024Review
- Placenta DNA methylation levels of the promoter region of the leptin receptor gene are associated with infant cortisol.Psychoneuroendocrinology · 2023Article
- Neonatal intensive care admission for term neonates and subsequent childhood mortality: a retrospective linkage study.BMC medicine · 2023Article
- Differentially methylated regions identified in bovine embryos are not observed in adulthood.Animal reproduction · 2023Article
- Recent progress in epigenetics of obesity.Diabetology & metabolic syndrome · 2022Review
- Effects of Sex and Obesity onInternational journal of molecular sciences · 2022Article
- Leptin in Human Milk-One of the Key Regulators of Nutritional Programming.Molecules (Basel, Switzerland) · 2022Review
- Epigenetics provides a bridge between early nutrition and long-term health and a target for disease prevention.Acta paediatrica (Oslo, Norway : 1992) · 2022Review
- Maternal obesity and the impact of associated early-life inflammation on long-term health of offspring.Frontiers in cellular and infection microbiology · 2022Review
- DNA methylation and regulation of gene expression: Guardian of our health.The Nucleus : an international journal of cytology and allied topics · 2021Review
- In utero nutritional stress as a cause of obesity: Altered relationship between body fat, leptin levels and caloric intake in offspring into adulthood.Life sciences · 2020Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundMaternal diet is an important factor in prenatal development that also has implications for disease risk later in life. The adipokine leptin is a key regulator of energy homeostasis and may be involved in the association between maternal nutrition, maternal obesity, and infant outcomes. DNA methylation of placenta genes may occur in response to exposures and may program subsequent infant development. This study examined maternal diet, placenta leptin gene DNA methylation, and neonatal growth in a sample of healthy neonates and their mothers.
methodsMothers and their healthy neonates (N = 135) were recruited within 1-2 days following delivery at Women and Infants Hospital in Providence, RI. A structured interview was conducted to assess maternal dietary intake. Maternal pre-pregnancy weight, weight gain during pregnancy, maternal health, medications, and vitamin use were obtained from medical records. Bisulfite pyrosequencing was used to measure methylation of CpG sites in the promoter region of the placenta leptin gene and determine genotype of the leptin single nucleotide polymorphism (SNP) rs2167270, which is known to influence leptin methylation. Bivariate analyses and linear regression models were used to evaluate associations of demographics, diet, and mean leptin methylation.
resultsGenotype was a significant predictor of placenta leptin DNA methylation (p < .01), and after controlling for this and other relevant maternal and infant covariates, lower levels of leptin methylation were significantly associated with greater intake of carbohydrates (p < .05), in particular added sugars (p < .05) and white/refined carbohydrates (p < .05). Total caloric intake was also associated with placenta leptin methylation (p < .05), however after controlling for relevant covariates, significance diminished to trend-level. There were no significant associations of placenta leptin methylation and intake of protein (p > .05) or fat (p > .05).
conclusionThese findings underline the importance of intake of carbohydrate consumption for methylation of the placenta leptin gene. Because methylation reduces gene transcription, lower methylation may indicate a placenta response to high caloric intake and carbohydrate food that would result in higher levels of this hormone during fetal development. Further investigation of the developmental ramifications of epigenetic changes to placenta leptin methylation should be pursued.
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