ArticleThe Journal of allergy and clinical immunology2020
Clinical factors associated with acute exacerbations of chronic rhinosinusitis.
Article in The Journal of allergy and clinical immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- The Microbiology of Acute Exacerbations in Chronic Rhinosinusitis - A Systematic Review.Frontiers in cellular and infection microbiology · 2022Pooled it
- Definition and characteristics of acute exacerbation in adult patients with chronic rhinosinusitis: a systematic review.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2020Pooled it
- Comparative Outcomes of Amoxicillin and Amoxicillin-Clavulanate in the Treatment of Acute Rhinosinusitis in Adults with Comorbidities: A Retrospective Study.Antibiotics (Basel, Switzerland) · 2026Article
- Obesity and New-Onset Asthma Risk in Chronic Rhinosinusitis: A Population-Based Cohort Study.Laryngoscope investigative otolaryngology · 2026Article
- Acute Exacerbations of Chronic Rhinosinusitis.Current allergy and asthma reports · 2025Review
- A cost utility analysis for the management of acute exacerbations of chronic rhinosinusitis.International forum of allergy & rhinology · 2025Article
- Rare constituents of the nasal microbiome contribute to the acute exacerbation of chronic rhinosinusitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- Definition of sinonasal and otological exacerbation in patients with primary ciliary dyskinesia: an expert consensus.ERJ open research · 2024Article
- Association of mucus eosinophil-derived neurotoxin levels with disease control status in patients with chronic rhinosinusitis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- The causal relationship between autoimmune diseases and rhinosinusitis, and the mediating role of inflammatory proteins: a Mendelian randomization study.Experimental biology and medicine (Maywood, N.J.) · 2024Article
- Host-microbe interactions in chronic rhinosinusitis biofilms and models for investigation.Biofilm · 2023Review
- Sinus inflammation and chronic rhinosinusitis are associated with a diagnosis of new onset asthma in the following year.Allergy · 2023Article
- Cross-sectional study to describe allergic rhinitis flare-ups and associated airways phenotype in house dust mite sensitization.PloS one · 2023Observational
- Acute exacerbations of chronic rhinosinusitis: The current state of knowledge.Laryngoscope investigative otolaryngology · 2022Review
- Impact of type 2 targeting biologics on acute exacerbations of chronic rhinosinusitis.Allergy and asthma proceedings · 2021Article
- Chronic rhinosinusitis and premorbid autoimmune diseases: a population-based case-control study.Scientific reports · 2020Article
- Acute exacerbation of chronic rhinosinusitis: clinical and microbiological perspectives from a Saudi tertiary care center.Annals of Saudi medicineArticle
- Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
backgroundChronic rhinosinusitis (CRS) is complicated by frequent acute exacerbations leading to significant health care burden and impaired quality of life.
objectiveThe objective of this study was to identify clinical factors associated with frequent acute exacerbation of CRS (AECRS).
methodsThis is a retrospective cohort study of patients with CRS from January 1, 2014, to May 31, 2016. Frequent AECRS was defined as at least 4 episodes over a 12-month period in which an antibiotic was prescribed for worsening sinus symptoms, and infrequent AECRS was defined as 0 to 3 episodes. Clinical factors, including asthma, allergic rhinitis, eosinophil count of at least 150 cells per microliter, and autoimmune disease, were evaluated for associations between the 2 groups.
resultsOf the 3109 patients with CRS who were identified, 600 (19.3%) were classified as having frequent exacerbation. Asthma, allergic rhinitis, eosinophil count of at least 150 cells per microliter, and autoimmune disease were associated with frequent AECRS with statistically significant adjusted odds ratios (aORs) after controlling for age, race, and sex in multivariate analysis (asthma aOR = 2.61 [95% CI = 2.14-3.18]; allergic rhinitis aOR = 1.96 [95% CI = 1.58-2.42]; eosinophil count of at least 150 cells per microliter aOR = 1.54 [95% CI = 1.21-1.97]; and autoimmune disease aOR = 1.68 [95% CI = 1.36-2.07]). Antibody deficiency, antibiotic allergy, lower FEV
conclusionPatients with frequent episodes of AECRS were characterized by a higher prevalence of asthma, allergic rhinitis, eosinophil count of at least 150 cells per microliter, autoimmune disease, and other allergic and immunologic diseases. These findings identify a high-risk phenotype of patients with CRS for preventive interventions to reduce exacerbation frequency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.