ArticleJournal of molecular and cellular cardiology2020
Global knockout of ROMK potassium channel worsens cardiac ischemia-reperfusion injury but cardiomyocyte-specific knockout does not: Implications for the identity of mitoKATP.
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Article in Journal of molecular and cellular cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Loss of O-GlcNAc transferase activity impairs the dynamic formation of protective stress granules in ischemic cardiomyocytes.The Biochemical journal · 2026Article
- BDNF/TrkB Signaling in Intracardiac Ganglia Modulates Cardiac Parasympathetic Tone.International journal of molecular sciences · 2026Article
- Pharmacologic ROMK Inhibition Protects Against Myocardial Ischemia Reperfusion Injury.International journal of molecular sciences · 2025Article
- Characterizing molecular and behavioral changes arising from ROMK potassium channel deficiency in the cerebellum.Frontiers in behavioral neuroscience · 2025Article
- Association of TyG index and central obesity with hypertension in middle-aged and elderly Chinese adults: a prospective cohort study.Scientific reports · 2024Article
- Kir1.1 and SUR1 are not implicated as subunits of an adenosine triphosphate-sensitive potassium channel involved in diazoxide cardioprotection.JTCVS open · 2023Article
- Overexpression of a Short Sulfonylurea Splice Variant Increases Cardiac Glucose Uptake and Uncouples Mitochondria by Regulating ROMK Activity.Life (Basel, Switzerland) · 2023Article
- Computational modeling of mitochondrial KJournal of molecular and cellular cardiology · 2022Article
- Review
- Alternative Targets for Modulators of Mitochondrial Potassium Channels.Molecules (Basel, Switzerland) · 2022Review
- ATP Synthase KFunction (Oxford, England) · 2022Article
- The Mitochondrial Routing of the Kv1.3 Channel.Frontiers in oncology · 2022Article
- Functional Regulation of KFrontiers in pharmacology · 2022Review
- Rethinking Mitchell's Chemiosmotic Theory: Potassium Dominates Over Proton Flux to Drive Mitochondrial FFunction (Oxford, England) · 2022Article
- Mitochondrial ion channels in cardiac function.American journal of physiology. Cell physiology · 2021Review
- Routes for Potassium Ions across Mitochondrial Membranes: A Biophysical Point of View with Special Focus on the ATP-Sensitive KBiomolecules · 2021Review
- Review
- Mitochondrial Potassium Channels as Druggable Targets.Biomolecules · 2020Review
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Authors and funding
14 authors at 5 institutions in 2 countries.
Kyriakos N PapanicolaouDivision of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Deepthi AshokDivision of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ting LiuDivision of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Tyler M BauerCardiovascular Branch, NHLBI, NIH, 10 Center Drive, Bethesda, MD, USA.
Junhui SunCardiovascular Branch, NHLBI, NIH, 10 Center Drive, Bethesda, MD, USA.
Zhen LiCardiovascular Center of Excellence, Louisiana State University (LSU) Health Sciences Center, New Orleans, LA, USA; Department of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, New Orleans, LA, USA.
Eduardo da CostaDivision of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Charles Crepy D'OrleansDivision of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sara NathanDivision of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
David J LeferCardiovascular Center of Excellence, Louisiana State University (LSU) Health Sciences Center, New Orleans, LA, USA; Department of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, New Orleans, LA, USA.
Elizabeth MurphyCardiovascular Branch, NHLBI, NIH, 10 Center Drive, Bethesda, MD, USA.
Nazareno PaolocciDivision of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Biomedical Sciences, University of Padova, Padova, Italy.
D Brian FosterDivision of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Brian O'RourkeDivision of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: bor@jhmi.edu.
Johns Hopkins University · USJohns Hopkins Medicine · USLouisiana State University Health Sciences Center New Orleans · USNational Institutes of Health · USNational Heart Lung and Blood Institute · US
Funding
Mechanisms of cardiac ischemia-reperfusion injury and cardioprotectionZIAHL002066 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI MURPHY, ELIZABETH · 2009 to 2025
$20.4MImmersive Training in GlycosciencesK12HL141952 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HASCALL, VINCENT CHARLES, SCHNAAR, RONALD L · 2018 to 2022
$4.8MBDNF TrkB- and beta-AR signals in ischemic and non-ischemic cardiomyopathyR01HL136918 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI PAOLOCCI, NAZARENO · 2018 to 2021
$2.7MTargeting Metabo-Redox Network Vulnerability in Heart Failure and Sudden DeathR01HL134821 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI FOSTER, D BRIAN, O'ROURKE, BRIAN · 2018 to 2021
$2.1MMolecular Determinants of Mitochondrial Instability and ArrhythmiasR01HL137259 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI AKAR, FADI GABRIEL, O'ROURKE, BRIAN · 2017 to 2020
$2.0MCardioprotective Actions of Hydrogen SulfideR01HL092141 · NHLBI · LSU HEALTH SCIENCES CENTER · PI LEFER, DAVID JOSEPH · 2009 to 2013
$1.9MHeart Failure Therapy by CRISPR-Mediated Upregulation of Mitochondrial BiogenesisF31HL134198 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI ASHOK, DEEPTHI · 2016 to 2018
$132kIntramural NIH HHS ZIA HL002066NHLBI NIH HHS F31 HL134198NHLBI NIH HHS K12 HL141952NHLBI NIH HHS R01 HL092141NHLBI NIH HHS R01 HL134821NHLBI NIH HHS R01 HL136918NHLBI NIH HHS R01 HL137259
Abstract
The renal-outer-medullary‑potassium (ROMK) channel, mutated in Bartter's syndrome, regulates ion exchange in kidney, but its extra-renal functions remain unknown. Additionally, ROMK was postulated to be the pore-forming subunit of the mitochondrial ATP-sensitive K
Indexed as
AnimalsAnimals, NewbornCalciumCRISPR-Cas SystemsElectrophysiological PhenomenaGene EditingGene Knockout TechniquesHemodynamicsIschemic Preconditioning, MyocardialMice, KnockoutMitochondria, HeartMyocardial Reperfusion InjuryMyocardiumMyocytes, CardiacOrgan SpecificityPerfusionCalciumKcnj1 protein, mousemitochondrial K(ATP) channelPotassium ChannelsPotassium Channels, Inwardly RectifyingBartter's syndromeIschemic preconditioningKcnj1 or Kir1.1 or ROMKMitochondrial ATP-sensitive potassium channelMitochondrial permeability transition poreRenal potassium channel
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.